| Identification |
|---|
| HMDB Protein ID
| HMDBP13495 |
| Secondary Accession Numbers
| None |
| Name
| Plasminogen |
| Synonyms
|
Not Available
|
| Gene Name
| PLG |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells (By similarity). |
| Pathways
|
- Complement and coagulation cascades
- Influenza A
- Neuroactive ligand-receptor interaction
- Staphylococcus aureus infection
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| fibrinolysis |
| response to heat |
| tissue remodeling |
| blood coagulation |
| Cellular Component |
| extracellular region |
| Molecular Function |
| receptor binding |
| protein domain specific binding |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 812 |
| Molecular Weight
| 91215.415 |
| Theoretical pI
| 7.501 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P06868 |
| UniProtKB/Swiss-Prot Entry Name
| PLMN_BOVIN |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Malinowski DP, Sadler JE, Davie EW: Characterization of a complementary deoxyribonucleic acid coding for human and bovine plasminogen. Biochemistry. 1984 Aug 28;23(18):4243-50. [PubMed:6148961 ]
- Marti T, Schaller J, Rickli EE, Schmid K, Kamerling JP, Gerwig GJ, van Halbeek H, Vliegenthart JF: The N- and O-linked carbohydrate chains of human, bovine and porcine plasminogen. Species specificity in relation to sialylation and fucosylation patterns. Eur J Biochem. 1988 Apr 5;173(1):57-63. [PubMed:3356193 ]
- Schaller J, Moser PW, Dannegger-Muller GA, Rosselet SJ, Kampfer U, Rickli EE: Complete amino acid sequence of bovine plasminogen. Comparison with human plasminogen. Eur J Biochem. 1985 Jun 3;149(2):267-78. doi: 10.1111/j.1432-1033.1985.tb08921.x. [PubMed:3846532 ]
|
