| Identification |
|---|
| HMDB Protein ID
| HMDBP13496 |
| Secondary Accession Numbers
| None |
| Name
| Thrombin-like enzyme BjussuSP-1 |
| Synonyms
|
- SVTLE BjussuSP-1
- Fibrinogen-clotting enzyme
- Jararacussin-I
- Snake venom serine protease 1
- Thrombin-like enzyme BjussuSP-I
- SVSP
- SVTLE BjussuSP-I
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Thrombin-like enzyme that shows clotting activity upon human plasma. Shows specific fibrinogenolytic activity for Aalpha chain (FGA). Hydrolyzes fibrin, BAPNA and TAME, as well as chromogenic artificial substrates of the blood coagulation cascasde: S-27654 for factor X (F10), S-2302 for kallikrein (KLK), factor XIa (F11), and XIIa (F12), and S-2266 for kallikrein and factor XIa (F11). Subcutaneous injection into mice induces a mild edema. Intravenous and intramuscular injection reduce plasma fibrinogen concentration and increase the levels of fibrin(ogen) degradation products. Intramuscular injection also promotes an increase in the expression of proMMP-9, but is unable to activate it. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 25162.325 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q2PQJ3 |
| UniProtKB/Swiss-Prot Entry Name
| VSP1_BOTJR |
| PDB IDs
|
|
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Sant'Ana CD, Bernardes CP, Izidoro LF, Mazzi MV, Soares SG, Fuly AL, Zingali RB, Magro AJ, Braz AS, Fontes MR, Stabeli RG, Sampaio SV, Soares AM: Molecular characterization of BjussuSP-I, a new thrombin-like enzyme with procoagulant and kallikrein-like activity isolated from Bothrops jararacussu snake venom. Biochimie. 2008 Mar;90(3):500-7. doi: 10.1016/j.biochi.2007.10.005. Epub 2007 Oct 18. [PubMed:17996740 ]
- Sant' Ana CD, Ticli FK, Oliveira LL, Giglio JR, Rechia CGV, Fuly AL, Selistre de Araujo HS, Franco JJ, Stabeli RG, Soares AM, Sampaio SV: BjussuSP-I: a new thrombin-like enzyme isolated from Bothrops jararacussu snake venom. Comp Biochem Physiol A Mol Integr Physiol. 2008 Nov;151(3):443-454. doi: 10.1016/j.cbpa.2007.02.036. Epub 2007 Mar 7. [PubMed:17466550 ]
- Perez AV, Saravia P, Rucavado A, Sant'Ana CD, Soares AM, Gutierrez JM: Local and systemic pathophysiological alterations induced by a serine proteinase from the venom of the snake Bothrops jararacussu. Toxicon. 2007 Jun 1;49(7):1063-9. doi: 10.1016/j.toxicon.2006.12.011. Epub 2007 Jan 5. [PubMed:17292935 ]
- Ullah A, Souza TA, Zanphorlin LM, Mariutti RB, Santana VS, Murakami MT, Arni RK: Crystal structure of Jararacussin-I: the highly negatively charged catalytic interface contributes to macromolecular selectivity in snake venom thrombin-like enzymes. Protein Sci. 2013 Jan;22(1):128-32. doi: 10.1002/pro.2189. [PubMed:23139169 ]
|
