| Identification |
|---|
| HMDB Protein ID
| HMDBP13499 |
| Secondary Accession Numbers
| None |
| Name
| Thrombin-like enzyme halystase |
| Synonyms
|
- SVTLE
- Snake venom serine protease
- SVSP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Thrombin-like snake venom serine protease. Cleaves fibrinogen (beta chain of fibrinogen (FGB) and more slowly alpha chain (FGA)) without inducing fibrin clotting and cleaves kininogen to produce bradykinin (KNG), resulting in the reduction of blood pressure. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| regulation of blood pressure |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| serine-type endopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 26483.025 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P81176 |
| UniProtKB/Swiss-Prot Entry Name
| VSP1_GLOBL |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Matsui T, Sakurai Y, Fujimura Y, Hayashi I, Oh-Ishi S, Suzuki M, Hamako J, Yamamoto Y, Yamazaki J, Kinoshita M, Titani K: Purification and amino acid sequence of halystase from snake venom of Agkistrodon halys blomhoffii, a serine protease that cleaves specifically fibrinogen and kininogen. Eur J Biochem. 1998 Mar 15;252(3):569-75. doi: 10.1046/j.1432-1327.1998.2520569.x. [PubMed:9546675 ]
|
