| Identification |
|---|
| HMDB Protein ID
| HMDBP13501 |
| Secondary Accession Numbers
| None |
| Name
| Zinc metalloproteinase-disintegrin-like VLAIP-B |
| Synonyms
|
- Snake venom metalloproteinase
- SVMP
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| This metalloproteinase hydrolyzes azocasein, and insulin B-chain (at the '38-Ala-|-Leu-39' bond). Also hydrolyzes the Aalpha-chain (FGA) and more slowly the Bbeta-chain of fibrinogen (FGB), without affecting the gamma-chain. Cleaves alpha-chain of fibrinogen at '432-Lys-|-Leu-433' and '535-Pro-|-Met-536' bonds. Does not cleave fibrin. Inhibits endothelial cell adhesion to extracellular matrix proteins such as fibrinogen, fibronectin, vitronectin, collagen I, and collagen IV. Induces apoptosis in vascular endothelial cells. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| apoptotic process |
| Cellular Component |
| extracellular region |
| Molecular Function |
| metal ion binding |
| toxin activity |
| metalloendopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 68842.635 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q4VM07 |
| UniProtKB/Swiss-Prot Entry Name
| VM3VB_MACLB |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Trummal K, Tonismagi K, Siigur E, Aaspollu A, Lopp A, Sillat T, Saat R, Kasak L, Tammiste I, Kogerman P, Kalkkinen N, Siigur J: A novel metalloprotease from Vipera lebetina venom induces human endothelial cell apoptosis. Toxicon. 2005 Jul;46(1):46-61. doi: 10.1016/j.toxicon.2005.03.008. [PubMed:15922394 ]
|
