| Identification |
|---|
| HMDB Protein ID
| HMDBP13505 |
| Secondary Accession Numbers
| None |
| Name
| Zinc metalloproteinase partitagin |
| Synonyms
|
Not Available
|
| Gene Name
| Not Available |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Zinc metalloproteinase that causes hemorrhage in mice following intradermal injection and impairs hemostasis in its prey. In skin tissues, it degrades components of the basement membrane surrounding blood vessels and capillaries. In muscle tissue, it degrades the extracellular matrix, thus causing muscle necrosis. However, it lacks direct toxicity on myocytes. Hydrolyzes alpha-2 chain (COL4A2) of type IV collagen more slowly than the alpha-1 chain (COL4A1). Hydrolyzes fibronectin (FN1). It also impairs hemostasis by acting on fibrin(ogen) and platelets. Shows fibrinolytic activity, with a selective degradation of gamma-dimer (FGG). Shows fibrinogenolytic activity by preferentially cleaving the Bbeta chain, and later gamma-chain. Aalpha-chain remains resistant to proteolytic digestion. Weakly inhibits collagen-triggered platelet aggregation of human plasma rich platelet. |
| Pathways
|
Not Available
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| envenomation resulting in blood vessel extracellular matrix damage, causing hemorrhagic damage in other organism |
| negative regulation of blood coagulation in other organism |
| proteolysis in other organism |
| Cellular Component |
| extracellular region |
| Molecular Function |
| toxin activity |
| metalloendopeptidase activity |
| zinc ion binding |
| metallopeptidase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| Not Available |
| Molecular Weight
| 2333.55 |
| Theoretical pI
| Not Available |
| Pfam Domain Function
|
Not Available |
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P85975 |
| UniProtKB/Swiss-Prot Entry Name
| VMPAR_HIPPR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Nagaraju S, Girish KS, Fox JW, Kemparaju K: 'Partitagin' a hemorrhagic metalloprotease from Hippasa partita spider venom: role in tissue necrosis. Biochimie. 2007 Nov;89(11):1322-31. doi: 10.1016/j.biochi.2007.04.005. Epub 2007 Apr 21. [PubMed:17555860 ]
- Shivaiah N, Kempaiah K: 'Partitagin', a unique beta, gamma-fibrinogenase that inhibits platelet aggregation from Hippasa partita spider venom. Blood Coagul Fibrinolysis. 2011 Jan;22(1):24-8. doi: 10.1097/MBC.0b013e32833fcc15. [PubMed:21150580 ]
|
