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Showing Protein Fibrinogen alpha chain (HMDBP13512)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13512
Secondary Accession Numbers None
Name Fibrinogen alpha chain
Synonyms Not Available
Gene Name FGA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen beta (FGB) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the immune response via both innate and T-cell mediated pathways.
Pathways
  • Complement and coagulation cascades
  • Coronavirus disease - COVID-19
  • Neutrophil extracellular trap formation
  • Platelet activation
Reactions Not Available
GO Classification
Biological Process
fibrinolysis
platelet degranulation
positive regulation of vasoconstriction
protein polymerization
blood coagulation, common pathway
blood coagulation, fibrin clot formation
induction of bacterial agglutination
negative regulation of blood coagulation, common pathway
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
extracellular matrix organization
platelet aggregation
response to calcium ion
positive regulation of protein secretion
post-translational protein modification
cellular protein metabolic process
negative regulation of endothelial cell apoptotic process
positive regulation of ERK1 and ERK2 cascade
blood coagulation
innate immune response
adaptive immune response
toll-like receptor signaling pathway
plasminogen activation
amyloid fibril formation
cellular protein-containing complex assembly
positive regulation of substrate adhesion-dependent cell spreading
protein-containing complex assembly
positive regulation of exocytosis
cell-matrix adhesion
Cellular Component
cell surface
platelet alpha granule lumen
cell cortex
fibrinogen complex
platelet alpha granule
extracellular vesicular exosome
plasma membrane
blood microparticle
endoplasmic reticulum lumen
synapse
extracellular region
collagen-containing extracellular matrix
extracellular space
external side of plasma membrane
extracellular vesicle
Molecular Function
metal ion binding
receptor binding
extracellular matrix structural constituent
structural molecule activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 866
Molecular Weight 94972.455
Theoretical pI 6.012
Pfam Domain Function
Signals
  • 1-19;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P02671
UniProtKB/Swiss-Prot Entry Name FIBA_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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