Hmdb loader
Identification
HMDB Protein ID HMDBP13513
Secondary Accession Numbers None
Name Fibronectin
Synonyms
  1. FN
Gene Name FN1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape (By similarity). Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity).Binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
regulation of cell shape
blood coagulation, fibrin clot formation
cell-substrate junction assembly
platelet aggregation
acute-phase response
heart development
angiogenesis
nervous system development
cell-matrix adhesion
Cellular Component
extracellular region
collagen-containing extracellular matrix
extracellular space
Molecular Function
proteoglycan binding
receptor binding
integrin binding
disordered domain specific binding
heparin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 272151.935
Theoretical pI Not Available
Pfam Domain Function
Signals
  • 1-32;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P07589
UniProtKB/Swiss-Prot Entry Name FINC_BOVIN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Kornblihtt AR, Vibe-Pedersen K, Baralle FE: Isolation and characterization of cDNA clones for human and bovine fibronectins. Proc Natl Acad Sci U S A. 1983 Jun;80(11):3218-22. [PubMed:6304699 ]
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  3. Skorstengaard K, Jensen MS, Sahl P, Petersen TE, Magnusson S: Complete primary structure of bovine plasma fibronectin. Eur J Biochem. 1986 Dec 1;161(2):441-53. doi: 10.1111/j.1432-1033.1986.tb10464.x. [PubMed:3780752 ]
  4. Petersen TE, Thogersen HC, Skorstengaard K, Vibe-Pedersen K, Sahl P, Sottrup-Jensen L, Magnusson S: Partial primary structure of bovine plasma fibronectin: three types of internal homology. Proc Natl Acad Sci U S A. 1983 Jan;80(1):137-41. doi: 10.1073/pnas.80.1.137. [PubMed:6218503 ]
  5. Darula Z, Medzihradszky KF: Affinity enrichment and characterization of mucin core-1 type glycopeptides from bovine serum. Mol Cell Proteomics. 2009 Nov;8(11):2515-26. doi: 10.1074/mcp.M900211-MCP200. Epub 2009 Aug 12. [PubMed:19674964 ]
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