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Showing Protein Fibrinogen beta chain (HMDBP13514)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13514
Secondary Accession Numbers None
Name Fibrinogen beta chain
Synonyms Not Available
Gene Name FGB
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Pathways
  • Complement and coagulation cascades
  • Coronavirus disease - COVID-19
  • Neutrophil extracellular trap formation
  • Platelet activation
Reactions Not Available
GO Classification
Biological Process
fibrinolysis
platelet degranulation
positive regulation of vasoconstriction
protein polymerization
blood coagulation, fibrin clot formation
induction of bacterial agglutination
cellular response to leptin stimulus
negative regulation of extrinsic apoptotic signaling pathway via death domain receptors
positive regulation of heterotypic cell-cell adhesion
positive regulation of peptide hormone secretion
extracellular matrix organization
platelet aggregation
cell adhesion
response to calcium ion
positive regulation of protein secretion
negative regulation of endothelial cell apoptotic process
cellular response to interleukin-1
positive regulation of ERK1 and ERK2 cascade
blood coagulation
innate immune response
adaptive immune response
toll-like receptor signaling pathway
plasminogen activation
cellular protein-containing complex assembly
positive regulation of substrate adhesion-dependent cell spreading
positive regulation of exocytosis
cell-matrix adhesion
Cellular Component
cell surface
platelet alpha granule lumen
cell cortex
fibrinogen complex
platelet alpha granule
endoplasmic reticulum
extracellular vesicular exosome
plasma membrane
blood microparticle
synapse
extracellular region
collagen-containing extracellular matrix
extracellular space
external side of plasma membrane
extracellular vesicle
Molecular Function
receptor binding
chaperone binding
extracellular matrix structural constituent
structural molecule activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 491
Molecular Weight 55927.9
Theoretical pI 8.271
Pfam Domain Function
Signals
  • 1-30;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P02675
UniProtKB/Swiss-Prot Entry Name FIBB_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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