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Showing Protein Platelet glycoprotein VI (HMDBP13515)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13515
Secondary Accession Numbers None
Name Platelet glycoprotein VI
Synonyms
  1. GPVI
  2. Glycoprotein 5
Gene Name GP6
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Collagen receptor involved in collagen-induced platelet adhesion and activation (PubMed:16139873, PubMed:24368846). Plays a key role in platelet procoagulant activity and subsequent thrombin and fibrin formation. This procoagulant function may contribute to arterial and venous thrombus formation. The signaling pathway involves the FcR gamma-chain, the Src kinases (likely FYN or LYN) and SYK, the adapter protein LAT and leads to the activation of PLCG2.
Pathways
  • ECM-receptor interaction
  • Platelet activation
Reactions Not Available
GO Classification
Biological Process
collagen-activated signaling pathway
collagen-activated tyrosine kinase receptor signaling pathway
blood coagulation
Cellular Component
tetraspanin-enriched microdomain
integral to plasma membrane
Molecular Function
collagen receptor activity
collagen binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 313
Molecular Weight 34594.3
Theoretical pI 8.567
Pfam Domain Function
Signals
  • 1-21;
Transmembrane Regions
  • 266-286;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P0C191
UniProtKB/Swiss-Prot Entry Name GPVI_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [PubMed:19468303 ]
  2. Pokidysheva E, Boudko S, Vranka J, Zientek K, Maddox K, Moser M, Fassler R, Ware J, Bachinger HP: Biological role of prolyl 3-hydroxylation in type IV collagen. Proc Natl Acad Sci U S A. 2014 Jan 7;111(1):161-6. doi: 10.1073/pnas.1307597111. Epub 2013 Dec 24. [PubMed:24368846 ]
  3. Jandrot-Perrus M, Busfield S, Lagrue AH, Xiong X, Debili N, Chickering T, Le Couedic JP, Goodearl A, Dussault B, Fraser C, Vainchenker W, Villeval JL: Cloning, characterization, and functional studies of human and mouse glycoprotein VI: a platelet-specific collagen receptor from the immunoglobulin superfamily. Blood. 2000 Sep 1;96(5):1798-807. [PubMed:10961879 ]
  4. Munnix IC, Strehl A, Kuijpers MJ, Auger JM, van der Meijden PE, van Zandvoort MA, oude Egbrink MG, Nieswandt B, Heemskerk JW: The glycoprotein VI-phospholipase Cgamma2 signaling pathway controls thrombus formation induced by collagen and tissue factor in vitro and in vivo. Arterioscler Thromb Vasc Biol. 2005 Dec;25(12):2673-8. doi: 10.1161/01.ATV.0000193568.71980.4a. Epub 2005 Oct 27. [PubMed:16254207 ]
  5. Lockyer S, Okuyama K, Begum S, Le S, Sun B, Watanabe T, Matsumoto Y, Yoshitake M, Kambayashi J, Tandon NN: GPVI-deficient mice lack collagen responses and are protected against experimentally induced pulmonary thromboembolism. Thromb Res. 2006;118(3):371-80. doi: 10.1016/j.thromres.2005.08.001. Epub 2005 Sep 2. [PubMed:16139873 ]