Hmdb loader

Showing Protein Fibrinogen gamma-B chain (HMDBP13517)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13517
Secondary Accession Numbers None
Name Fibrinogen gamma-B chain
Synonyms
  1. Gamma'
Gene Name FGG
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Together with fibrinogen alpha (FGA) and fibrinogen beta (FGB), polymerizes to form an insoluble fibrin matrix. Has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re-epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However, subsequent studies have shown that it is not absolutely required for thrombus formation in vivo. Enhances expression of SELP in activated platelets via an ITGB3-dependent pathway. Maternal fibrinogen is essential for successful pregnancy. Fibrin deposition is also associated with infection, where it protects against IFNG-mediated hemorrhage. May also facilitate the antibacterial immune response via both innate and T-cell mediated pathways.
Pathways
  • Complement and coagulation cascades
  • Coronavirus disease - COVID-19
  • Neutrophil extracellular trap formation
  • Platelet activation
  • Staphylococcus aureus infection
Reactions Not Available
GO Classification
Biological Process
protein polymerization
blood coagulation, fibrin clot formation
platelet aggregation
cell-matrix adhesion
Cellular Component
fibrinogen complex
collagen-containing extracellular matrix
extracellular space
Molecular Function
metal ion binding
receptor binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 444
Molecular Weight 50243.745
Theoretical pI 5.83
Pfam Domain Function
Signals
  • 1-24;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P12799
UniProtKB/Swiss-Prot Entry Name FIBG_BOVIN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Brown WM, Dziegielewska KM, Foreman RC, Saunders NR: Nucleotide and deduced amino acid sequence of a gamma subunit of bovine fibrinogen. Nucleic Acids Res. 1989 Aug 11;17(15):6397. doi: 10.1093/nar/17.15.6397. [PubMed:2771651 ]
  2. Timpl R, Fietzek PP, Wachter E, Van Delden V: Disulfide-linked cyanogen bromide peptides of bovine fibrinogen. II. Isolation and sequence analysis of the chain constituents from the amino terminal region. Biochim Biophys Acta. 1977 Feb 22;490(2):420-9. doi: 10.1016/0005-2795(77)90017-4. [PubMed:836881 ]
  3. Sharp JJ, Cassman KG, Doolittle RF: Amino acid sequence of the carboxy-terminal cyanogen bromide fragment from bovine and human fibrinogen gamma-chains. FEBS Lett. 1972 Sep 15;25(2):334-336. doi: 10.1016/0014-5793(72)80517-9. [PubMed:11946783 ]
  4. Brown JH, Volkmann N, Jun G, Henschen-Edman AH, Cohen C: The crystal structure of modified bovine fibrinogen. Proc Natl Acad Sci U S A. 2000 Jan 4;97(1):85-90. doi: 10.1073/pnas.97.1.85. [PubMed:10618375 ]
  5. Madrazo J, Brown JH, Litvinovich S, Dominguez R, Yakovlev S, Medved L, Cohen C: Crystal structure of the central region of bovine fibrinogen (E5 fragment) at 1.4-A resolution. Proc Natl Acad Sci U S A. 2001 Oct 9;98(21):11967-72. doi: 10.1073/pnas.211439798. [PubMed:11593005 ]