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Identification
HMDB Protein ID HMDBP13521
Secondary Accession Numbers None
Name Prothrombin
Synonyms
  1. Coagulation factor II
Gene Name F2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing.
Pathways
  • Complement and coagulation cascades
  • Coronavirus disease - COVID-19
  • Neuroactive ligand-receptor interaction
  • Pathogenic Escherichia coli infection
  • Phospholipase D signaling pathway
  • Platelet activation
  • Regulation of actin cytoskeleton
Reactions Not Available
GO Classification
Biological Process
positive regulation of blood coagulation
negative regulation of cytokine production involved in inflammatory response
multicellular organismal development
positive regulation of reactive oxygen species metabolic process
fibrinolysis
platelet activation
regulation of cell shape
leukocyte migration
positive regulation of cell proliferation
cytolysis by host of symbiont cells
positive regulation of lipid kinase activity
positive regulation of phospholipase C-activating G protein-coupled receptor signaling pathway
regulation of complement activation
ER to Golgi vesicle-mediated transport
G-protein coupled receptor signaling pathway
acute-phase response
response to wounding
neutrophil-mediated killing of gram-negative bacterium
positive regulation of collagen biosynthetic process
cellular protein metabolic process
positive regulation of protein phosphorylation
cell surface receptor signaling pathway
blood coagulation
positive regulation of release of sequestered calcium ion into cytosol
antimicrobial humoral immune response mediated by antimicrobial peptide
cytosolic calcium ion homeostasis
blood coagulation, intrinsic pathway
negative regulation of fibrinolysis
positive regulation of cell growth
regulation of blood coagulation
proteolysis
negative regulation of proteolysis
positive regulation of protein localization to nucleus
negative regulation of platelet activation
positive regulation of phosphatidylinositol 3-kinase cascade
positive regulation of receptor signaling pathway via JAK-STAT
negative regulation of astrocyte differentiation
Cellular Component
Golgi lumen
extracellular vesicular exosome
plasma membrane
blood microparticle
endoplasmic reticulum lumen
extracellular region
collagen-containing extracellular matrix
extracellular space
Molecular Function
lipopolysaccharide binding
thrombospondin receptor activity
growth factor activity
enzyme activator activity
receptor binding
calcium ion binding
heparin binding
serine-type endopeptidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 622
Molecular Weight 70036.295
Theoretical pI 5.895
Pfam Domain Function
Signals
  • 1-24;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P00734
UniProtKB/Swiss-Prot Entry Name THRB_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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