Hmdb loader

Showing Protein Mitogen-activated protein kinase HOG1 (HMDBP13530)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13530
Secondary Accession Numbers None
Name Mitogen-activated protein kinase HOG1
Synonyms
  1. MAP kinase HOG1
Gene Name HOG1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes. Also involved in response UV radiations and mediates the sensitivity to fludioxonil, an agricultural fungicide.
Pathways
  • MAPK signaling pathway - yeast
  • Mitophagy - yeast
Reactions Not Available
GO Classification
Biological Process
osmosensory signaling pathway
stress-activated MAPK cascade
intracellular signal transduction
cellular response to oxidative stress
Cellular Component
cytoplasm
nucleus
Molecular Function
MAP kinase activity
ATP binding
protein serine kinase activity
protein serine/threonine kinase activity
protein threonine kinase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 365
Molecular Weight 41212.99
Theoretical pI 5.372
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P0CP68
UniProtKB/Swiss-Prot Entry Name HOG1_CRYNJ
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, Donlin MJ, D'Souza CA, Fox DS, Grinberg V, Fu J, Fukushima M, Haas BJ, Huang JC, Janbon G, Jones SJ, Koo HL, Krzywinski MI, Kwon-Chung JK, Lengeler KB, Maiti R, Marra MA, Marra RE, Mathewson CA, Mitchell TG, Pertea M, Riggs FR, Salzberg SL, Schein JE, Shvartsbeyn A, Shin H, Shumway M, Specht CA, Suh BB, Tenney A, Utterback TR, Wickes BL, Wortman JR, Wye NH, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, Hyman RW: The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321-4. doi: 10.1126/science.1103773. Epub 2005 Jan 13. [PubMed:15653466 ]
  2. Bahn YS, Kojima K, Cox GM, Heitman J: Specialization of the HOG pathway and its impact on differentiation and virulence of Cryptococcus neoformans. Mol Biol Cell. 2005 May;16(5):2285-300. doi: 10.1091/mbc.e04-11-0987. Epub 2005 Feb 23. [PubMed:15728721 ]
  3. Kojima K, Bahn YS, Heitman J: Calcineurin, Mpk1 and Hog1 MAPK pathways independently control fludioxonil antifungal sensitivity in Cryptococcus neoformans. Microbiology (Reading). 2006 Mar;152(Pt 3):591-604. doi: 10.1099/mic.0.28571-0. [PubMed:16514140 ]