Identification |
HMDB Protein ID
| HMDBP13557 |
Secondary Accession Numbers
| None |
Name
| Globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 |
Synonyms
|
- Forssman glycolipid synthase
|
Gene Name
| GBGT1 |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| Catalyzes the formation of Forssman glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to GalNAcb-1,3Gala-1,4Galb-1,4GlcCer (Gb4Cer) (PubMed:8855242, PubMed:10506200). Forssman glycolipid (also called Forssman antigen; FG) probably serves for adherence of some pathogens such as E.coli uropathogenic strains (PubMed:10506200). |
Pathways
|
- Glycosphingolipid biosynthesis - globo and isoglobo series
- protein glycosylation
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
globoside metabolic process |
protein glycosylation |
carbohydrate metabolic process |
Cellular Component |
integral to membrane |
Golgi membrane |
Molecular Function |
metal ion binding |
globoside alpha-N-acetylgalactosaminyltransferase activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 347 |
Molecular Weight
| 40265.16 |
Theoretical pI
| 8.899 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q95158 |
UniProtKB/Swiss-Prot Entry Name
| GBGT1_CANLF |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Xu H, Storch T, Yu M, Elliott SP, Haslam DB: Characterization of the human Forssman synthetase gene. An evolving association between glycolipid synthesis and host-microbial interactions. J Biol Chem. 1999 Oct 8;274(41):29390-8. [PubMed:10506200 ]
- Haslam DB, Baenziger JU: Expression cloning of Forssman glycolipid synthetase: a novel member of the histo-blood group ABO gene family. Proc Natl Acad Sci U S A. 1996 Oct 1;93(20):10697-702. doi: 10.1073/pnas.93.20.10697. [PubMed:8855242 ]
|