Hmdb loader
Identification
HMDB Protein ID HMDBP13560
Secondary Accession Numbers None
Name A type blood N-acetyl-alpha-D-galactosamine deacetylase
Synonyms
  1. CBM32
  2. FpGalNAc deacetylase
  3. FpGalNAcDeAc
Gene Name Not Available
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function One of an enzyme pair that work together to convert the A antigen to the H antigen of the O blood type, which together release galactosamine. Catalyzes the first step in the conversion, generating the substrate for the subsequent enzyme (FpGalNase, AC P0DTR5). Works on many different A antigen subtypes. Glu-90 probably activates a nucleophilic water molecule to start the deacetylation reaction.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
metabolic process
Molecular Function
hydrolase activity, acting on glycosyl bonds
metal ion binding
myelin-proteolipid O-palmitoyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 84440.475
Theoretical pI Not Available
Pfam Domain Function
Signals
  • 1-27;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P0DTR4
UniProtKB/Swiss-Prot Entry Name ADAC_FLAPL
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Rahfeld P, Sim L, Moon H, Constantinescu I, Morgan-Lang C, Hallam SJ, Kizhakkedathu JN, Withers SG: An enzymatic pathway in the human gut microbiome that converts A to universal O type blood. Nat Microbiol. 2019 Sep;4(9):1475-1485. doi: 10.1038/s41564-019-0469-7. Epub 2019 Jun 10. [PubMed:31182795 ]