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Identification
HMDB Protein ID HMDBP13562
Secondary Accession Numbers None
Name CMP-N-acetylneuraminate-beta-galactosamide-alpha-2,3-sialyltransferase 4
Synonyms
  1. Alpha 2,3-ST 4
  2. Beta-galactoside alpha-2,3-sialyltransferase 4
  3. Alpha 2,3-sialyltransferase IV
  4. Gal-beta-1,3-GalNAc-alpha-2,3-sialyltransferase
  5. Gal-beta-1,4-GlcNAc-alpha-2,3-sialyltransferase
  6. N-acetyllactosaminide alpha-2,3-sialyltransferase
  7. ST3Gal IV
  8. Sialyltransferase 4C
  9. ST3GalIV
  10. SIAT4-C
Gene Name ST3GAL4
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function A beta-galactoside alpha2-3 sialyltransferase involved in terminal sialylation of glycoproteins and glycolipids (PubMed:12097641) (By similarity). Catalyzes the transfer of sialic acid (N-acetyl-neuraminic acid; Neu5Ac) from the nucleotide sugar donor CMP-Neu5Ac onto acceptor Galbeta-(1->3)-GalNAc- and Galbeta-(1->4)-GlcNAc-terminated glycoconjugates through an alpha2-3 linkage (PubMed:9184827) (By similarity). Plays a major role in hemostasis. Responsible for sialylation of plasma VWF/von Willebrand factor, preventing its recognition by asialoglycoprotein receptors (ASGPR) and subsequent clearance. Regulates ASGPR-mediated clearance of platelets (PubMed:12097641). Participates in the biosynthesis of the sialyl Lewis X epitopes, both on O- and N-glycans, which are recognized by SELE/E-selectin, SELP/P-selectin and SELL/L-selectin. Essential for selectin-mediated rolling and adhesion of leukocytes during extravasation (PubMed:25498912). Contributes to adhesion and transendothelial migration of neutrophils likely through terminal sialylation of CXCR2 (PubMed:18519646). In glycosphingolipid biosynthesis, sialylates GM1 and GA1 gangliosides to form GD1a and GM1b, respectively (By similarity). Metabolizes brain c-series ganglioside GT1c forming GQ1c (By similarity). Synthesizes ganglioside LM1 (IV3Neu5Ac-nLc4Cer), a major structural component of peripheral nerve myelin (By similarity).
Pathways
  • Glycosphingolipid biosynthesis - lacto and neolacto series
  • protein glycosylation
Reactions Not Available
GO Classification
Biological Process
positive regulation of blood coagulation
oligosaccharide biosynthetic process
glycolipid biosynthetic process
lipid glycosylation
glycoprotein biosynthetic process
protein sialylation
sialylation
protein glycosylation
positive regulation of leukocyte tethering or rolling
cognition
Cellular Component
Golgi cisterna membrane
integral to membrane
Molecular Function
beta-galactoside (CMP) alpha-2,3-sialyltransferase activity
monosialoganglioside sialyltransferase activity
sialyltransferase activity
N-acetyllactosaminide alpha-2,3-sialyltransferase activity
neolactotetraosylceramide alpha-2,3-sialyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 333
Molecular Weight 38058.03
Theoretical pI 9.363
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 9-26;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q91Y74
UniProtKB/Swiss-Prot Entry Name SIA4C_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  3. Kono M, Ohyama Y, Lee YC, Hamamoto T, Kojima N, Tsuji S: Mouse beta-galactoside alpha 2,3-sialyltransferases: comparison of in vitro substrate specificities and tissue specific expression. Glycobiology. 1997 Jun;7(4):469-79. doi: 10.1093/glycob/7.4.469. [PubMed:9184827 ]
  4. Okabe A, Tawara Y, Masa T, Oka T, Machida A, Tanaka T, Matsuhashi H, Shiosaka S, Kato K: Differential expression of mRNAs for sialyltransferase isoenzymes induced in the hippocampus of mouse following kindled seizures. J Neurochem. 2001 Jun;77(5):1185-97. doi: 10.1046/j.1471-4159.2001.00319.x. [PubMed:11389169 ]
  5. Ellies LG, Ditto D, Levy GG, Wahrenbrock M, Ginsburg D, Varki A, Le DT, Marth JD: Sialyltransferase ST3Gal-IV operates as a dominant modifier of hemostasis by concealing asialoglycoprotein receptor ligands. Proc Natl Acad Sci U S A. 2002 Jul 23;99(15):10042-7. doi: 10.1073/pnas.142005099. Epub 2002 Jul 3. [PubMed:12097641 ]
  6. Mondal N, Buffone A Jr, Stolfa G, Antonopoulos A, Lau JT, Haslam SM, Dell A, Neelamegham S: ST3Gal-4 is the primary sialyltransferase regulating the synthesis of E-, P-, and L-selectin ligands on human myeloid leukocytes. Blood. 2015 Jan 22;125(4):687-96. doi: 10.1182/blood-2014-07-588590. Epub 2014 Dec 10. [PubMed:25498912 ]