Hmdb loader
Identification
HMDB Protein ID HMDBP13565
Secondary Accession Numbers None
Name Galactoside alpha-(1,2)-fucosyltransferase 2
Synonyms
  1. Alpha(1,2)FT 2
  2. Fucosyltransferase 2
  3. GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
  4. Secretor factor
  5. Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
  6. Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
  7. Se
Gene Name FUT2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation (PubMed:10814703). Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition (By similarity). Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway (PubMed:20506485).
Pathways
  • Glycosphingolipid biosynthesis - globo and isoglobo series
  • Glycosphingolipid biosynthesis - lacto and neolacto series
  • protein glycosylation
Reactions Not Available
GO Classification
Biological Process
protein glycosylation
fucosylation
regulation of cell adhesion
regulation of endothelial cell proliferation
glycolipid metabolic process
carbohydrate metabolic process
Cellular Component
Golgi cisterna membrane
integral to membrane
Molecular Function
galactoside 2-alpha-L-fucosyltransferase activity
alpha-(1,2)-fucosyltransferase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 344
Molecular Weight 39319.905
Theoretical pI 8.765
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 8-28;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q28113
UniProtKB/Swiss-Prot Entry Name FUT2_BOVIN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Barreaud JP, Saunier K, Souchaire J, Delourme D, Oulmouden A, Oriol R, Leveziel H, Julien R, Petit JM: Three bovine alpha2-fucosyltransferase genes encode enzymes that preferentially transfer fucose on Galbeta1-3GalNAc acceptor substrates. Glycobiology. 2000 Jun;10(6):611-21. doi: 10.1093/glycob/10.6.611. [PubMed:10814703 ]
  2. Palumberi D, Aldi S, Ermini L, Ziche M, Finetti F, Donnini S, Rosati F: RNA-mediated gene silencing of FUT1 and FUT2 influences expression and activities of bovine and human fucosylated nucleolin and inhibits cell adhesion and proliferation. J Cell Biochem. 2010 Sep 1;111(1):229-38. doi: 10.1002/jcb.22692. [PubMed:20506485 ]