| Identification |
|---|
| HMDB Protein ID
| HMDBP13567 |
| Secondary Accession Numbers
| None |
| Name
| Galactoside alpha-(1,2)-fucosyltransferase 2 |
| Synonyms
|
- Alpha(1,2)FT 2
- Fucosyltransferase 2
- GDP-L-fucose:beta-D-galactoside 2-alpha-L-fucosyltransferase 2
- Type 1 galactoside alpha-(1,2)-fucosyltransferase FUT2
- Type 2 galactoside alpha-(1,2)-fucosyltransferase FUT2
|
| Gene Name
| FUT2 |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Catalyzes the transfer of L-fucose, from a guanosine diphosphate-beta-L-fucose, to the terminal galactose on both O- and N-linked glycans chains of cell surface glycoproteins and glycolipids and the resulting epitope regulates several processes such as cell-cell interaction including host-microbe interaction, cell surface expression and cell proliferation. Preferentially fucosylates gangliosides GA1 and GM1 in the antrum, cecum and colon and in the female reproductive organs. Fucosylated host glycoproteins or glycolipids mediate interaction with intestinal microbiota influencing its composition. Creates a soluble precursor oligosaccharide FuC-alpha ((1,2)Galbeta-) called the H antigen which is an essential substrate for the final step in the soluble ABO blood group antigen synthesis pathway. |
| Pathways
|
- Glycosphingolipid biosynthesis - globo and isoglobo series
- Glycosphingolipid biosynthesis - lacto and neolacto series
- protein glycosylation
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| protein glycosylation |
| fucosylation |
| regulation of cell adhesion |
| regulation of endothelial cell proliferation |
| glycolipid metabolic process |
| carbohydrate metabolic process |
| Cellular Component |
| Golgi cisterna membrane |
| integral to membrane |
| Molecular Function |
| galactoside 2-alpha-L-fucosyltransferase activity |
| alpha-(1,2)-fucosyltransferase activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 343 |
| Molecular Weight
| 38998.83 |
| Theoretical pI
| 8.544 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| O77485 |
| UniProtKB/Swiss-Prot Entry Name
| FUT2_PANTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Apoil PA, Roubinet F, Despiau S, Mollicone R, Oriol R, Blancher A: Evolution of alpha 2-fucosyltransferase genes in primates: relation between an intronic Alu-Y element and red cell expression of ABH antigens. Mol Biol Evol. 2000 Mar;17(3):337-51. doi: 10.1093/oxfordjournals.molbev.a026314. [PubMed:10723735 ]
|
