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Showing Protein Synaptotagmin-7 (HMDBP13579)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13579
Secondary Accession Numbers None
Name Synaptotagmin-7
Synonyms
  1. Synaptotagmin VII
  2. SytVII
Gene Name SYT7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Ca(2+) sensor involved in Ca(2+)-dependent exocytosis of secretory and synaptic vesicles through Ca(2+) and phospholipid binding to the C2 domain. Ca(2+) induces binding of the C2-domains to phospholipid membranes and to assembled SNARE-complexes; both actions contribute to triggering exocytosis. SYT7 binds Ca(2+) with high affinity and slow kinetics compared to other synaptotagmins (PubMed:26738595). Involved in Ca(2+)-triggered lysosomal exocytosis, a major component of the plasma membrane repair (By similarity). Ca(2+)-regulated delivery of lysosomal membranes to the cell surface is also involved in the phagocytic uptake of particles by macrophages (PubMed:16982801, PubMed:21041449). Ca(2+)-triggered lysosomal exocytosis also plays a role in bone remodeling by regulating secretory pathways in osteoclasts and osteoblasts (PubMed:18539119). Involved in cholesterol transport from lysosome to peroxisome by promoting membrane contacts between lysosomes and peroxisomes: probably acts by promoting vesicle fusion by binding phosphatidylinositol-4,5-bisphosphate on peroxisomal membranes (PubMed:25860611). Acts as a key mediator of synaptic facilitation, a process also named short-term synaptic potentiation: synaptic facilitation takes place at synapses with a low initial release probability and is caused by influx of Ca(2+) into the axon terminal after spike generation, increasing the release probability of neurotransmitters (PubMed:24569478, PubMed:26738595). Probably mediates synaptic facilitation by directly increasing the probability of release (PubMed:26738595). May also contribute to synaptic facilitation by regulating synaptic vesicle replenishment, a process required to ensure that synaptic vesicles are ready for the arrival of the next action potential: SYT7 is required for synaptic vesicle replenishment by acting as a sensor for Ca(2+) and by forming a complex with calmodulin (PubMed:24569478). Also acts as a regulator of Ca(2+)-dependent insulin and glucagon secretion in beta-cells (PubMed:18308938, PubMed:19171650). Triggers exocytosis by promoting fusion pore opening and fusion pore expansion in chromaffin cells (PubMed:20956309). Also regulates the secretion of some non-synaptic secretory granules of specialized cells (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
cellular response to calcium ion
phagocytosis
regulation of glucagon secretion
calcium ion regulated lysosome exocytosis
phagosome-lysosome fusion
calcium ion-regulated exocytosis of neurotransmitter
calcium-dependent activation of synaptic vesicle fusion
plasma membrane repair
regulation of bone remodeling
regulation of calcium ion-dependent exocytosis
regulation of dopamine secretion
regulation of phagocytosis
short-term synaptic potentiation
synaptic vesicle recycling
vesicle-mediated cholesterol transport
regulation of synaptic vesicle endocytosis
vesicle-mediated transport
regulation of insulin secretion
calcium ion-dependent exocytosis
Cellular Component
cytosol
plasma membrane
dendrite
presynaptic membrane
synaptic vesicle
phagocytic vesicle membrane
axon terminus
lysosome
exocytic vesicle
peroxisomal membrane
early phagosome
glutamatergic synapse
neuronal cell body
peroxisome
GABA-ergic synapse
lysosomal membrane
integral to membrane
synaptic vesicle membrane
Molecular Function
phosphatidylinositol-4,5-bisphosphate binding
calcium-dependent phospholipid binding
clathrin binding
phosphatidylserine binding
SNARE binding
calcium ion binding
calmodulin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 403
Molecular Weight 45471.96
Theoretical pI 9.272
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 17-37;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9R0N7
UniProtKB/Swiss-Prot Entry Name SYT7_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  5. Fukuda M, Kanno E, Mikoshiba K: Conserved N-terminal cysteine motif is essential for homo- and heterodimer formation of synaptotagmins III, V, VI, and X. J Biol Chem. 1999 Oct 29;274(44):31421-7. doi: 10.1074/jbc.274.44.31421. [PubMed:10531343 ]
  6. Fukuda M, Ogata Y, Saegusa C, Kanno E, Mikoshiba K: Alternative splicing isoforms of synaptotagmin VII in the mouse, rat and human. Biochem J. 2002 Jul 1;365(Pt 1):173-80. doi: 10.1042/BJ20011877. [PubMed:12071850 ]
  7. Fukuda M, Mikoshiba K: Distinct self-oligomerization activities of synaptotagmin family. Unique calcium-dependent oligomerization properties of synaptotagmin VII. J Biol Chem. 2000 Sep 8;275(36):28180-5. doi: 10.1074/jbc.M001376200. [PubMed:10871604 ]
  8. Sugita S, Han W, Butz S, Liu X, Fernandez-Chacon R, Lao Y, Sudhof TC: Synaptotagmin VII as a plasma membrane Ca(2+) sensor in exocytosis. Neuron. 2001 May;30(2):459-73. doi: 10.1016/s0896-6273(01)00290-2. [PubMed:11395007 ]
  9. Chakrabarti S, Kobayashi KS, Flavell RA, Marks CB, Miyake K, Liston DR, Fowler KT, Gorelick FS, Andrews NW: Impaired membrane resealing and autoimmune myositis in synaptotagmin VII-deficient mice. J Cell Biol. 2003 Aug 18;162(4):543-9. doi: 10.1083/jcb.200305131. [PubMed:12925704 ]
  10. Czibener C, Sherer NM, Becker SM, Pypaert M, Hui E, Chapman ER, Mothes W, Andrews NW: Ca2+ and synaptotagmin VII-dependent delivery of lysosomal membrane to nascent phagosomes. J Cell Biol. 2006 Sep 25;174(7):997-1007. doi: 10.1083/jcb.200605004. Epub 2006 Sep 18. [PubMed:16982801 ]
  11. Li Y, Wang P, Xu J, Gorelick F, Yamazaki H, Andrews N, Desir GV: Regulation of insulin secretion and GLUT4 trafficking by the calcium sensor synaptotagmin VII. Biochem Biophys Res Commun. 2007 Oct 26;362(3):658-64. doi: 10.1016/j.bbrc.2007.08.023. Epub 2007 Aug 15. [PubMed:17720139 ]
  12. Zhao H, Ito Y, Chappel J, Andrews NW, Teitelbaum SL, Ross FP: Synaptotagmin VII regulates bone remodeling by modulating osteoclast and osteoblast secretion. Dev Cell. 2008 Jun;14(6):914-25. doi: 10.1016/j.devcel.2008.03.022. [PubMed:18539119 ]
  13. Gustavsson N, Wei SH, Hoang DN, Lao Y, Zhang Q, Radda GK, Rorsman P, Sudhof TC, Han W: Synaptotagmin-7 is a principal Ca2+ sensor for Ca2+ -induced glucagon exocytosis in pancreas. J Physiol. 2009 Mar 15;587(Pt 6):1169-78. doi: 10.1113/jphysiol.2008.168005. Epub 2009 Jan 26. [PubMed:19171650 ]
  14. Flannery AR, Czibener C, Andrews NW: Palmitoylation-dependent association with CD63 targets the Ca2+ sensor synaptotagmin VII to lysosomes. J Cell Biol. 2010 Nov 1;191(3):599-613. doi: 10.1083/jcb.201003021. [PubMed:21041449 ]
  15. Segovia M, Ales E, Montes MA, Bonifas I, Jemal I, Lindau M, Maximov A, Sudhof TC, Alvarez de Toledo G: Push-and-pull regulation of the fusion pore by synaptotagmin-7. Proc Natl Acad Sci U S A. 2010 Nov 2;107(44):19032-7. doi: 10.1073/pnas.1014070107. Epub 2010 Oct 18. [PubMed:20956309 ]
  16. Liu H, Bai H, Hui E, Yang L, Evans CS, Wang Z, Kwon SE, Chapman ER: Synaptotagmin 7 functions as a Ca2+-sensor for synaptic vesicle replenishment. Elife. 2014 Feb 25;3:e01524. doi: 10.7554/eLife.01524. [PubMed:24569478 ]
  17. Chu BB, Liao YC, Qi W, Xie C, Du X, Wang J, Yang H, Miao HH, Li BL, Song BL: Cholesterol transport through lysosome-peroxisome membrane contacts. Cell. 2015 Apr 9;161(2):291-306. doi: 10.1016/j.cell.2015.02.019. [PubMed:25860611 ]
  18. Barthet G, Jorda-Siquier T, Rumi-Masante J, Bernadou F, Muller U, Mulle C: Presenilin-mediated cleavage of APP regulates synaptotagmin-7 and presynaptic plasticity. Nat Commun. 2018 Nov 14;9(1):4780. doi: 10.1038/s41467-018-06813-x. [PubMed:30429473 ]
  19. Xue M, Craig TK, Shin OH, Li L, Brautigam CA, Tomchick DR, Sudhof TC, Rosenmund C, Rizo J: Structural and mutational analysis of functional differentiation between synaptotagmins-1 and -7. PLoS One. 2010 Sep 2;5(9). doi: 10.1371/journal.pone.0012544. [PubMed:20824061 ]