Hmdb loader
Identification
HMDB Protein ID HMDBP13582
Secondary Accession Numbers None
Name High mobility group nucleosome-binding domain-containing protein 3
Synonyms
  1. Thyroid receptor-interacting protein 7
  2. TR-interacting protein 7
  3. TRIP-7
Gene Name HMGN3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function (By similarity).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
chromatin organization
regulation of insulin secretion involved in cellular response to glucose stimulus
positive regulation of transcription from RNA polymerase II promoter
Cellular Component
cytosol
nucleus
nucleoplasm
chromatin
Molecular Function
thyroid hormone receptor binding
nucleosomal DNA binding
chromatin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 99
Molecular Weight 10665.8
Theoretical pI 9.664
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q15651
UniProtKB/Swiss-Prot Entry Name HMGN3_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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