Hmdb loader
Identification
HMDB Protein ID HMDBP13583
Secondary Accession Numbers None
Name Brefeldin A-inhibited guanine nucleotide-exchange protein 3
Synonyms
  1. ARFGEF family member 3
Gene Name ARFGEF3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells (PubMed:19496786).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
negative regulation of phosphatase activity
regulation of ARF protein signal transduction
actin cytoskeleton organization
Cellular Component
transport vesicle membrane
integral to membrane
Molecular Function
guanyl-nucleotide exchange factor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 2177
Molecular Weight 240649.14
Theoretical pI 5.819
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 1492-1512;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q5TH69
UniProtKB/Swiss-Prot Entry Name BIG3_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Nakajima D, Okazaki N, Yamakawa H, Kikuno R, Ohara O, Nagase T: Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. DNA Res. 2002 Jun 30;9(3):99-106. [PubMed:12168954 ]
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  9. Kim JW, Akiyama M, Park JH, Lin ML, Shimo A, Ueki T, Daigo Y, Tsunoda T, Nishidate T, Nakamura Y, Katagiri T: Activation of an estrogen/estrogen receptor signaling by BIG3 through its inhibitory effect on nuclear transport of PHB2/REA in breast cancer. Cancer Sci. 2009 Aug;100(8):1468-78. doi: 10.1111/j.1349-7006.2009.01209.x. Epub 2009 May 6. [PubMed:19496786 ]