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Identification
HMDB Protein ID HMDBP13588
Secondary Accession Numbers None
Name Transcription factor MafB
Synonyms
  1. Maf-B
  2. V-maf musculoaponeurotic fibrosarcoma oncogene homolog B
Gene Name MAFB
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acts as a transcriptional activator or repressor (PubMed:27181683). Plays a pivotal role in regulating lineage-specific hematopoiesis by repressing ETS1-mediated transcription of erythroid-specific genes in myeloid cells. Required for monocytic, macrophage, osteoclast, podocyte and islet beta cell differentiation. Involved in renal tubule survival and F4/80 maturation. Activates the insulin and glucagon promoters. Together with PAX6, transactivates weakly the glucagon gene promoter through the G1 element. SUMO modification controls its transcriptional activity and ability to specify macrophage fate. Binds element G1 on the glucagon promoter (By similarity). Involved either as an oncogene or as a tumor suppressor, depending on the cell context. Required for the transcriptional activation of HOXB3 in the rhombomere r5 in the hindbrain (By similarity).
Pathways
  • Parathyroid hormone synthesis, secretion and action
Reactions Not Available
GO Classification
Biological Process
fat cell differentiation
T cell differentiation in thymus
thymus development
respiratory gaseous exchange
regulation of transcription from RNA polymerase II promoter
inner ear morphogenesis
positive regulation of transcription, DNA-dependent
abducens nerve formation
brain segmentation
negative regulation of erythrocyte differentiation
regulation of myeloid cell differentiation
rhombomere 5 development
rhombomere 6 development
segment specification
sensory organ development
negative regulation of osteoclast differentiation
regulation of transcription, DNA-dependent
Cellular Component
nucleus
chromatin
transcription factor complex
Molecular Function
protein-containing complex binding
sequence-specific DNA binding
DNA-binding transcription activator activity, RNA polymerase II-specific
transcription factor binding
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 323
Molecular Weight 35791.58
Theoretical pI 7.633
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Y5Q3
UniProtKB/Swiss-Prot Entry Name MAFB_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  4. Eychene A, Rocques N, Pouponnot C: A new MAFia in cancer. Nat Rev Cancer. 2008 Sep;8(9):683-93. doi: 10.1038/nrc2460. [PubMed:19143053 ]
  5. Wang PW, Eisenbart JD, Cordes SP, Barsh GS, Stoffel M, Le Beau MM: Human KRML (MAFB): cDNA cloning, genomic structure, and evaluation as a candidate tumor suppressor gene in myeloid leukemias. Genomics. 1999 Aug 1;59(3):275-81. doi: 10.1006/geno.1999.5884. [PubMed:10444328 ]
  6. Petersen HH, Hilpert J, Jacobsen C, Lauwers A, Roebroek AJ, Willnow TE: Low-density lipoprotein receptor-related protein interacts with MafB, a regulator of hindbrain development. FEBS Lett. 2004 May 7;565(1-3):23-7. doi: 10.1016/j.febslet.2004.03.069. [PubMed:15135046 ]
  7. Sii-Felice K, Pouponnot C, Gillet S, Lecoin L, Girault JA, Eychene A, Felder-Schmittbuhl MP: MafA transcription factor is phosphorylated by p38 MAP kinase. FEBS Lett. 2005 Jul 4;579(17):3547-54. doi: 10.1016/j.febslet.2005.04.086. [PubMed:15963504 ]
  8. Rocques N, Abou Zeid N, Sii-Felice K, Lecoin L, Felder-Schmittbuhl MP, Eychene A, Pouponnot C: GSK-3-mediated phosphorylation enhances Maf-transforming activity. Mol Cell. 2007 Nov 30;28(4):584-97. doi: 10.1016/j.molcel.2007.11.009. [PubMed:18042454 ]
  9. Zankl A, Duncan EL, Leo PJ, Clark GR, Glazov EA, Addor MC, Herlin T, Kim CA, Leheup BP, McGill J, McTaggart S, Mittas S, Mitchell AL, Mortier GR, Robertson SP, Schroeder M, Terhal P, Brown MA: Multicentric carpotarsal osteolysis is caused by mutations clustering in the amino-terminal transcriptional activation domain of MAFB. Am J Hum Genet. 2012 Mar 9;90(3):494-501. doi: 10.1016/j.ajhg.2012.01.003. Epub 2012 Mar 1. [PubMed:22387013 ]