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Identification
HMDB Protein ID HMDBP13609
Secondary Accession Numbers None
Name Hydroxymethylglutaryl-CoA synthase, mitochondrial
Synonyms
  1. HMG-CoA synthase
  2. 3-hydroxy-3-methylglutaryl coenzyme A synthase
Gene Name HMGCS2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Catalyzes the first irreversible step in ketogenesis, condensing acetyl-CoA to acetoacetyl-CoA to form HMG-CoA, which is converted by HMG-CoA reductase (HMGCR) into mevalonate.
Pathways
  • (R)-mevalonate biosynthesis
  • Butanoate metabolism
  • PPAR signaling pathway
  • Terpenoid backbone biosynthesis
  • Valine, leucine and isoleucine degradation
Reactions Not Available
GO Classification
Biological Process
cholesterol biosynthetic process
ketone body biosynthetic process
farnesyl diphosphate biosynthetic process, mevalonate pathway
acetyl-CoA metabolic process
Cellular Component
mitochondrial matrix
mitochondrion
mitochondrial inner membrane
Molecular Function
hydroxymethylglutaryl-CoA synthase activity
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 508
Molecular Weight 56822.265
Theoretical pI 8.41
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P54869
UniProtKB/Swiss-Prot Entry Name HMCS2_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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