Hmdb loader
Survey

Showing Protein 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2 (HMDBP13613)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13613
Secondary Accession Numbers None
Name 3-hydroxy-3-methylglutaryl-coenzyme A reductase 2
Synonyms
  1. HMG-CoA reductase 2
Gene Name HMG2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function One of 2 isozymes that catalyze the conversion of HMG-CoA to mevalonate. It is the rate-limiting enzyme of the sterol biosynthesis pathway. Involved in ergosterol biosynthesis.
Pathways
  • (R)-mevalonate biosynthesis
  • Biosynthesis of secondary metabolites
  • Terpenoid backbone biosynthesis
Reactions Not Available
GO Classification
Biological Process
isoprenoid biosynthetic process
coenzyme A metabolic process
sterol biosynthetic process
ergosterol biosynthetic process
Cellular Component
endoplasmic reticulum membrane
endoplasmic reticulum
peroxisomal membrane
nuclear envelope
nuclear periphery
proteasome complex
integral to membrane
Molecular Function
hydroxymethylglutaryl-CoA reductase (NADPH) activity
hydroxymethylglutaryl-CoA reductase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1045
Molecular Weight 115690.63
Theoretical pI 7.577
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 25-45;187-207;217-237;244-264;302-322;325-345;403-423;498-518;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P12684
UniProtKB/Swiss-Prot Entry Name HMDH2_YEAST
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Engel SR, Dietrich FS, Fisk DG, Binkley G, Balakrishnan R, Costanzo MC, Dwight SS, Hitz BC, Karra K, Nash RS, Weng S, Wong ED, Lloyd P, Skrzypek MS, Miyasato SR, Simison M, Cherry JM: The reference genome sequence of Saccharomyces cerevisiae: then and now. G3 (Bethesda). 2014 Mar 20;4(3):389-98. doi: 10.1534/g3.113.008995. [PubMed:24374639 ]
  2. Ghaemmaghami S, Huh WK, Bower K, Howson RW, Belle A, Dephoure N, O'Shea EK, Weissman JS: Global analysis of protein expression in yeast. Nature. 2003 Oct 16;425(6959):737-41. doi: 10.1038/nature02046. [PubMed:14562106 ]
  3. Johnston M, Hillier L, Riles L, Albermann K, Andre B, Ansorge W, Benes V, Bruckner M, Delius H, Dubois E, Dusterhoft A, Entian KD, Floeth M, Goffeau A, Hebling U, Heumann K, Heuss-Neitzel D, Hilbert H, Hilger F, Kleine K, Kotter P, Louis EJ, Messenguy F, Mewes HW, Hoheisel JD, et al.: The nucleotide sequence of Saccharomyces cerevisiae chromosome XII. Nature. 1997 May 29;387(6632 Suppl):87-90. [PubMed:9169871 ]
  4. Kim H, Melen K, Osterberg M, von Heijne G: A global topology map of the Saccharomyces cerevisiae membrane proteome. Proc Natl Acad Sci U S A. 2006 Jul 25;103(30):11142-7. doi: 10.1073/pnas.0604075103. Epub 2006 Jul 17. [PubMed:16847258 ]
  5. Li X, Gerber SA, Rudner AD, Beausoleil SA, Haas W, Villen J, Elias JE, Gygi SP: Large-scale phosphorylation analysis of alpha-factor-arrested Saccharomyces cerevisiae. J Proteome Res. 2007 Mar;6(3):1190-7. doi: 10.1021/pr060559j. [PubMed:17330950 ]
  6. Albuquerque CP, Smolka MB, Payne SH, Bafna V, Eng J, Zhou H: A multidimensional chromatography technology for in-depth phosphoproteome analysis. Mol Cell Proteomics. 2008 Jul;7(7):1389-96. doi: 10.1074/mcp.M700468-MCP200. Epub 2008 Apr 11. [PubMed:18407956 ]
  7. Basson ME, Thorsness M, Finer-Moore J, Stroud RM, Rine J: Structural and functional conservation between yeast and human 3-hydroxy-3-methylglutaryl coenzyme A reductases, the rate-limiting enzyme of sterol biosynthesis. Mol Cell Biol. 1988 Sep;8(9):3797-808. doi: 10.1128/mcb.8.9.3797-3808.1988. [PubMed:3065625 ]
  8. Hu Y, Rolfs A, Bhullar B, Murthy TV, Zhu C, Berger MF, Camargo AA, Kelley F, McCarron S, Jepson D, Richardson A, Raphael J, Moreira D, Taycher E, Zuo D, Mohr S, Kane MF, Williamson J, Simpson A, Bulyk ML, Harlow E, Marsischky G, Kolodner RD, LaBaer J: Approaching a complete repository of sequence-verified protein-encoding clones for Saccharomyces cerevisiae. Genome Res. 2007 Apr;17(4):536-43. doi: 10.1101/gr.6037607. Epub 2007 Feb 23. [PubMed:17322287 ]
  9. Basson ME, Thorsness M, Rine J: Saccharomyces cerevisiae contains two functional genes encoding 3-hydroxy-3-methylglutaryl-coenzyme A reductase. Proc Natl Acad Sci U S A. 1986 Aug;83(15):5563-7. doi: 10.1073/pnas.83.15.5563. [PubMed:3526336 ]
  10. Koning AJ, Roberts CJ, Wright RL: Different subcellular localization of Saccharomyces cerevisiae HMG-CoA reductase isozymes at elevated levels corresponds to distinct endoplasmic reticulum membrane proliferations. Mol Biol Cell. 1996 May;7(5):769-89. doi: 10.1091/mbc.7.5.769. [PubMed:8744950 ]
  11. Huh WK, Falvo JV, Gerke LC, Carroll AS, Howson RW, Weissman JS, O'Shea EK: Global analysis of protein localization in budding yeast. Nature. 2003 Oct 16;425(6959):686-91. doi: 10.1038/nature02026. [PubMed:14562095 ]