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Identification
HMDB Protein ID HMDBP13667
Secondary Accession Numbers None
Name G-protein coupled receptor 35
Synonyms
  1. Kynurenic acid receptor
  2. KYNA receptor
Gene Name GPR35
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Acts as a receptor for kynurenic acid, an intermediate in the tryptophan metabolic pathway. The activity of this receptor is mediated by G-proteins that elicit calcium mobilization and inositol phosphate production through G(qi/o) proteins.
Pathways
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
elevation of cytosolic calcium ion concentration
G-protein coupled receptor signaling pathway
positive regulation of Rho protein signal transduction
cytoskeleton organization
chemokine-mediated signaling pathway
negative regulation of neuronal action potential
elevation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway
negative regulation of voltage-gated calcium channel activity
Cellular Component
plasma membrane
integral to plasma membrane
Molecular Function
C-X-C chemokine receptor activity
G protein-coupled receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 309
Molecular Weight 34071.89
Theoretical pI 8.708
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 25-45;57-77;91-112;136-156;175-195;219-239;259-279;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9HC97
UniProtKB/Swiss-Prot Entry Name GPR35_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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