Identification |
HMDB Protein ID
| HMDBP13672 |
Secondary Accession Numbers
| None |
Name
| Relaxin-3 receptor 2 |
Synonyms
|
- RLN3 receptor 2
- G-protein coupled receptor 100
- Insulin-like peptide INSL5 receptor
- Relaxin family peptide receptor 4
|
Gene Name
| RXFP4 |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| High affinity receptor for INSL5. Also acts as receptor for RLN3/relaxin-3, as well as bradykinin and kallidin. Binding of the ligand inhibit cAMP accumulation (By similarity). |
Pathways
|
- Neuroactive ligand-receptor interaction
- Relaxin signaling pathway
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
neuropeptide signaling pathway |
positive regulation of feeding behavior |
Cellular Component |
integral to plasma membrane |
Molecular Function |
G-protein coupled peptide receptor activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 414 |
Molecular Weight
| 45459.635 |
Theoretical pI
| 8.105 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
- 44-64;78-98;117-137;156-176;210-230;256-276;294-316;
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| Q7TQP4 |
UniProtKB/Swiss-Prot Entry Name
| RL3R2_MOUSE |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Fredriksson R, Hoglund PJ, Gloriam DE, Lagerstrom MC, Schioth HB: Seven evolutionarily conserved human rhodopsin G protein-coupled receptors lacking close relatives. FEBS Lett. 2003 Nov 20;554(3):381-8. [PubMed:14623098 ]
- Vassilatis DK, Hohmann JG, Zeng H, Li F, Ranchalis JE, Mortrud MT, Brown A, Rodriguez SS, Weller JR, Wright AC, Bergmann JE, Gaitanaris GA: The G protein-coupled receptor repertoires of human and mouse. Proc Natl Acad Sci U S A. 2003 Apr 15;100(8):4903-8. doi: 10.1073/pnas.0230374100. Epub 2003 Apr 4. [PubMed:12679517 ]
|