Hmdb loader

Showing Protein Laccase-1 (HMDBP13699)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13699
Secondary Accession Numbers None
Name Laccase-1
Synonyms
  1. Diphenol oxidase 1
Gene Name LAC1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Laccase that catalyzes the oxidation of certain aromatic compounds, including L-dopa, to quinones, which then polymerize to melanin (PubMed:1100669, PubMed:6807845, PubMed:6804444, PubMed:8760791). Able to oxidize a wide variety of aromatic diphenol and diamino groups in the ortho, meta, and para positions but not monophenolic groups such as in phenol, tyramine, or tyrosine (PubMed:8300520). Plays an important role in virulence (PubMed:8760791). Plays a role in dissemination to extrapulmonary sites but is not involved in pulmonary growth or in elicitation of cellular immune responses in the lung (PubMed:14977977).
Pathways Not Available
Reactions Not Available
GO Classification
Cellular Component
extracellular region
cell wall
Molecular Function
copper ion binding
hydroquinone:oxygen oxidoreductase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 624
Molecular Weight 68269.845
Theoretical pI 5.56
Pfam Domain Function
Signals
  • 1-20;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q55P57
UniProtKB/Swiss-Prot Entry Name LAC1_CRYNB
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Loftus BJ, Fung E, Roncaglia P, Rowley D, Amedeo P, Bruno D, Vamathevan J, Miranda M, Anderson IJ, Fraser JA, Allen JE, Bosdet IE, Brent MR, Chiu R, Doering TL, Donlin MJ, D'Souza CA, Fox DS, Grinberg V, Fu J, Fukushima M, Haas BJ, Huang JC, Janbon G, Jones SJ, Koo HL, Krzywinski MI, Kwon-Chung JK, Lengeler KB, Maiti R, Marra MA, Marra RE, Mathewson CA, Mitchell TG, Pertea M, Riggs FR, Salzberg SL, Schein JE, Shvartsbeyn A, Shin H, Shumway M, Specht CA, Suh BB, Tenney A, Utterback TR, Wickes BL, Wortman JR, Wye NH, Kronstad JW, Lodge JK, Heitman J, Davis RW, Fraser CM, Hyman RW: The genome of the basidiomycetous yeast and human pathogen Cryptococcus neoformans. Science. 2005 Feb 25;307(5713):1321-4. doi: 10.1126/science.1103773. Epub 2005 Jan 13. [PubMed:15653466 ]
  2. Williamson PR: Biochemical and molecular characterization of the diphenol oxidase of Cryptococcus neoformans: identification as a laccase. J Bacteriol. 1994 Feb;176(3):656-64. doi: 10.1128/jb.176.3.656-664.1994. [PubMed:8300520 ]
  3. Xu J, Vilgalys R, Mitchell TG: Multiple gene genealogies reveal recent dispersion and hybridization in the human pathogenic fungus Cryptococcus neoformans. Mol Ecol. 2000 Oct;9(10):1471-81. doi: 10.1046/j.1365-294x.2000.01021.x. [PubMed:11050543 ]
  4. Chaskes S, Tyndall RL: Pigment production by Cryptococcus neoformans from para- and ortho-Diphenols: effect of the nitrogen source. J Clin Microbiol. 1975 Jun;1(6):509-14. doi: 10.1128/jcm.1.6.509-514.1975. [PubMed:1100669 ]
  5. Kwon-Chung KJ, Polacheck I, Popkin TJ: Melanin-lacking mutants of Cryptococcus neoformans and their virulence for mice. J Bacteriol. 1982 Jun;150(3):1414-21. doi: 10.1128/jb.150.3.1414-1421.1982. [PubMed:6804444 ]
  6. Salas SD, Bennett JE, Kwon-Chung KJ, Perfect JR, Williamson PR: Effect of the laccase gene CNLAC1, on virulence of Cryptococcus neoformans. J Exp Med. 1996 Aug 1;184(2):377-86. doi: 10.1084/jem.184.2.377. [PubMed:8760791 ]
  7. Zhu X, Gibbons J, Garcia-Rivera J, Casadevall A, Williamson PR: Laccase of Cryptococcus neoformans is a cell wall-associated virulence factor. Infect Immun. 2001 Sep;69(9):5589-96. doi: 10.1128/IAI.69.9.5589-5596.2001. [PubMed:11500433 ]
  8. Noverr MC, Williamson PR, Fajardo RS, Huffnagle GB: CNLAC1 is required for extrapulmonary dissemination of Cryptococcus neoformans but not pulmonary persistence. Infect Immun. 2004 Mar;72(3):1693-9. doi: 10.1128/IAI.72.3.1693-1699.2004. [PubMed:14977977 ]
  9. Zhu X, Williamson PR: Role of laccase in the biology and virulence of Cryptococcus neoformans. FEMS Yeast Res. 2004 Oct;5(1):1-10. doi: 10.1016/j.femsyr.2004.04.004. [PubMed:15381117 ]