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Showing Protein Phospholipase A-2-activating protein (HMDBP13752)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13752
Secondary Accession Numbers None
Name Phospholipase A-2-activating protein
Synonyms
  1. PLA2P
  2. PLAP
Gene Name PLAA
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Plays a role in protein ubiquitination, sorting and degradation through its association with VCP (PubMed:27753622). Involved in ubiquitin-mediated membrane proteins trafficking to late endosomes in an ESCRT-dependent manner, and hence plays a role in synaptic vesicle recycling (By similarity). May play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622). Plays a role in cerebellar Purkinje cell development (By similarity). Positively regulates cytosolic and calcium-independent phospholipase A2 activities in a tumor necrosis factor alpha (TNF-alpha)- or lipopolysaccharide (LPS)-dependent manner, and hence prostaglandin E2 biosynthesis (PubMed:18291623, PubMed:28007986).
Pathways
  • Protein processing in endoplasmic reticulum
Reactions Not Available
GO Classification
Biological Process
signal transduction
phospholipid metabolic process
inflammatory response
macroautophagy
positive regulation of neuron migration
negative regulation of protein K63-linked ubiquitination
positive regulation of dendrite extension
positive regulation of phospholipase A2 activity
positive regulation of synaptic vesicle recycling
ubiquitin recycling
ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
cellular response to lipopolysaccharide
prostaglandin metabolic process
nervous system development
proteasomal ubiquitin-dependent protein catabolic process
Cellular Component
cytoplasm
extracellular vesicular exosome
nucleus
synapse
Molecular Function
ubiquitin binding
phospholipase A2 activator activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 795
Molecular Weight 87156.21
Theoretical pI 6.372
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9Y263
UniProtKB/Swiss-Prot Entry Name PLAP_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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