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Showing Protein T-cell differentiation antigen CD6 (HMDBP13764)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 2 metabolites
Identification
HMDB Protein ID HMDBP13764
Secondary Accession Numbers None
Name T-cell differentiation antigen CD6
Synonyms
  1. T12
  2. TP120
Gene Name CD6
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Cell adhesion molecule that mediates cell-cell contacts and regulates T-cell responses via its interaction with ALCAM/CD166 (PubMed:15048703, PubMed:15294938, PubMed:16352806, PubMed:16914752, PubMed:24945728, PubMed:24584089). Contributes to signaling cascades triggered by activation of the TCR/CD3 complex (PubMed:24584089). Functions as costimulatory molecule; promotes T-cell activation and proliferation (PubMed:15294938, PubMed:16352806, PubMed:16914752). Contributes to the formation and maturation of the immunological synapse (PubMed:15294938, PubMed:16352806). Functions as calcium-dependent pattern receptor that binds and aggregates both Gram-positive and Gram-negative bacteria. Binds both lipopolysaccharide (LPS) from Gram-negative bacteria and lipoteichoic acid from Gram-positive bacteria (PubMed:17601777). LPS binding leads to the activation of signaling cascades and down-stream MAP kinases (PubMed:17601777). Mediates activation of the inflammatory response and the secretion of pro-inflammatory cytokines in response to LPS (PubMed:17601777).
Pathways
  • Cell adhesion molecules
Reactions Not Available
GO Classification
Biological Process
response to lipopolysaccharide
positive regulation of T cell proliferation
acute inflammatory response to antigenic stimulus
innate immune response
immunological synapse formation
heterophilic cell-cell adhesion
adaptive immune response
lipopolysaccharide-mediated signaling pathway
positive regulation of cytokine production involved in inflammatory response
Cellular Component
intrinsic component of plasma membrane
extracellular region
external side of plasma membrane
immunological synapse
integral to plasma membrane
Molecular Function
lipopolysaccharide binding
scavenger receptor activity
lipoteichoic acid binding
identical protein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 668
Molecular Weight 71800.185
Theoretical pI 4.915
Pfam Domain Function
Signals
  • 1-17;
Transmembrane Regions
  • 403-423;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P30203
UniProtKB/Swiss-Prot Entry Name CD6_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Taylor TD, Noguchi H, Totoki Y, Toyoda A, Kuroki Y, Dewar K, Lloyd C, Itoh T, Takeda T, Kim DW, She X, Barlow KF, Bloom T, Bruford E, Chang JL, Cuomo CA, Eichler E, FitzGerald MG, Jaffe DB, LaButti K, Nicol R, Park HS, Seaman C, Sougnez C, Yang X, Zimmer AR, Zody MC, Birren BW, Nusbaum C, Fujiyama A, Hattori M, Rogers J, Lander ES, Sakaki Y: Human chromosome 11 DNA sequence and analysis including novel gene identification. Nature. 2006 Mar 23;440(7083):497-500. [PubMed:16554811 ]
  2. Bowen MA, Whitney GS, Neubauer M, Starling GC, Palmer D, Zhang J, Nowak NJ, Shows TB, Aruffo A: Structure and chromosomal location of the human CD6 gene: detection of five human CD6 isoforms. J Immunol. 1997 Feb 1;158(3):1149-56. [PubMed:9013954 ]
  3. Aruffo A, Melnick MB, Linsley PS, Seed B: The lymphocyte glycoprotein CD6 contains a repeated domain structure characteristic of a new family of cell surface and secreted proteins. J Exp Med. 1991 Oct 1;174(4):949-52. doi: 10.1084/jem.174.4.949. [PubMed:1919444 ]
  4. Castro MA, Oliveira MI, Nunes RJ, Fabre S, Barbosa R, Peixoto A, Brown MH, Parnes JR, Bismuth G, Moreira A, Rocha B, Carmo AM: Extracellular isoforms of CD6 generated by alternative splicing regulate targeting of CD6 to the immunological synapse. J Immunol. 2007 Apr 1;178(7):4351-61. doi: 10.4049/jimmunol.178.7.4351. [PubMed:17371992 ]
  5. Swack JA, Mier JW, Romain PL, Hull SR, Rudd CE: Biosynthesis and post-translational modification of CD6, a T cell signal-transducing molecule. J Biol Chem. 1991 Apr 15;266(11):7137-43. [PubMed:2016320 ]
  6. Wee S, Schieven GL, Kirihara JM, Tsu TT, Ledbetter JA, Aruffo A: Tyrosine phosphorylation of CD6 by stimulation of CD3: augmentation by the CD4 and CD2 coreceptors. J Exp Med. 1993 Jan 1;177(1):219-23. doi: 10.1084/jem.177.1.219. [PubMed:7678115 ]
  7. Hassan NJ, Barclay AN, Brown MH: Frontline: Optimal T cell activation requires the engagement of CD6 and CD166. Eur J Immunol. 2004 Apr;34(4):930-40. doi: 10.1002/eji.200424856. [PubMed:15048703 ]
  8. Gimferrer I, Calvo M, Mittelbrunn M, Farnos M, Sarrias MR, Enrich C, Vives J, Sanchez-Madrid F, Lozano F: Relevance of CD6-mediated interactions in T cell activation and proliferation. J Immunol. 2004 Aug 15;173(4):2262-70. doi: 10.4049/jimmunol.173.4.2262. [PubMed:15294938 ]
  9. Hassan NJ, Simmonds SJ, Clarkson NG, Hanrahan S, Puklavec MJ, Bomb M, Barclay AN, Brown MH: CD6 regulates T-cell responses through activation-dependent recruitment of the positive regulator SLP-76. Mol Cell Biol. 2006 Sep;26(17):6727-38. doi: 10.1128/MCB.00688-06. [PubMed:16914752 ]
  10. Sarrias MR, Farnos M, Mota R, Sanchez-Barbero F, Ibanez A, Gimferrer I, Vera J, Fenutria R, Casals C, Yelamos J, Lozano F: CD6 binds to pathogen-associated molecular patterns and protects from LPS-induced septic shock. Proc Natl Acad Sci U S A. 2007 Jul 10;104(28):11724-9. doi: 10.1073/pnas.0702815104. Epub 2007 Jun 29. [PubMed:17601777 ]
  11. Escoda-Ferran C, Carrasco E, Caballero-Banos M, Miro-Julia C, Martinez-Florensa M, Consuegra-Fernandez M, Martinez VG, Liu FT, Lozano F: Modulation of CD6 function through interaction with Galectin-1 and -3. FEBS Lett. 2014 Aug 25;588(17):2805-13. doi: 10.1016/j.febslet.2014.05.064. Epub 2014 Jun 16. [PubMed:24945728 ]
  12. Roncagalli R, Hauri S, Fiore F, Liang Y, Chen Z, Sansoni A, Kanduri K, Joly R, Malzac A, Lahdesmaki H, Lahesmaa R, Yamasaki S, Saito T, Malissen M, Aebersold R, Gstaiger M, Malissen B: Quantitative proteomics analysis of signalosome dynamics in primary T cells identifies the surface receptor CD6 as a Lat adaptor-independent TCR signaling hub. Nat Immunol. 2014 Apr;15(4):384-392. doi: 10.1038/ni.2843. Epub 2014 Mar 2. [PubMed:24584089 ]
  13. Chappell PE, Garner LI, Yan J, Metcalfe C, Hatherley D, Johnson S, Robinson CV, Lea SM, Brown MH: Structures of CD6 and Its Ligand CD166 Give Insight into Their Interaction. Structure. 2015 Aug 4;23(8):1426-1436. doi: 10.1016/j.str.2015.05.019. Epub 2015 Jul 2. [PubMed:26146185 ]