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Showing Protein Lys-63-specific deubiquitinase BRCC36 (HMDBP13773)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13773
Secondary Accession Numbers None
Name Lys-63-specific deubiquitinase BRCC36
Synonyms
  1. BRCA1-A complex subunit BRCC36
  2. BRCA1/BRCA2-containing complex subunit 3
  3. BRCA1/BRCA2-containing complex subunit 36
  4. BRISC complex subunit BRCC36
Gene Name BRCC3
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains (PubMed:19214193, PubMed:20656690, PubMed:24075985, PubMed:26344097). Does not have activity toward 'Lys-48'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). In the BRCA1-A complex, it specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX, antagonizing the RNF8-dependent ubiquitination at double-strand breaks (DSBs) (PubMed:20656690). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:20656690, PubMed:24075985, PubMed:26344097, PubMed:26195665). Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex (PubMed:19214193). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).
Pathways
  • Homologous recombination
  • NOD-like receptor signaling pathway
Reactions Not Available
GO Classification
Biological Process
cell cycle
protein deubiquitination
cell division
double-strand break repair via nonhomologous end joining
response to ionizing radiation
double-strand break repair
response to X-ray
protein K63-linked deubiquitination
histone H2A K63-linked deubiquitination
signal transduction involved in G2 DNA damage checkpoint
positive regulation of DNA repair
Cellular Component
cytosol
cytoplasm
nucleus
nucleoplasm
ubiquitin ligase complex
BRISC complex
BRCA1-A complex
nuclear ubiquitin ligase complex
spindle pole
Molecular Function
thiol-dependent deubiquitinase
metal ion binding
isopeptidase activity
metallopeptidase activity
polyubiquitin binding
enzyme regulator activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 316
Molecular Weight 36071.695
Theoretical pI 5.919
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P46736
UniProtKB/Swiss-Prot Entry Name BRCC3_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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