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Showing Protein C-C chemokine receptor type 4 (HMDBP13777)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13777
Secondary Accession Numbers None
Name C-C chemokine receptor type 4
Synonyms
  1. C-C CKR-4
  2. CC-CKR-4
  3. CCR-4
  4. CCR4
Gene Name CCR4
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function High affinity receptor for the C-C type chemokines CCL17/TARC and CCL22/MDC. The activity of this receptor is mediated by G(i) proteins which activate a phosphatidylinositol-calcium second messenger system. Could play a role in lipopolysaccharide (LPS)-induced endotoxic shock. In the CNS, could mediate hippocampal-neuron survival.
Pathways
  • Chemokine signaling pathway
  • Cytokine-cytokine receptor interaction
  • Kaposi sarcoma-associated herpesvirus infection
  • Viral carcinogenesis
  • Viral protein interaction with cytokine and cytokine receptor
Reactions Not Available
GO Classification
Biological Process
elevation of cytosolic calcium ion concentration
calcium-mediated signaling
cell chemotaxis
response to bacterium
chemotaxis
inflammatory response
neuron migration
homeostasis of number of cells
response to radiation
immune response
positive regulation of positive chemotaxis
tolerance induction
response to antibiotic
Cellular Component
plasma membrane
neuronal cell body
external side of plasma membrane
integral to membrane
Molecular Function
C-C chemokine binding
C-C chemokine receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 360
Molecular Weight 41407.285
Theoretical pI 7.308
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 40-67;78-98;112-133;151-175;207-226;243-267;285-308;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P51680
UniProtKB/Swiss-Prot Entry Name CCR4_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Hoogewerf A, Black D, Proudfoot AE, Wells TN, Power CA: Molecular cloning of murine CC CKR-4 and high affinity binding of chemokines to murine and human CC CKR-4. Biochem Biophys Res Commun. 1996 Jan 5;218(1):337-43. doi: 10.1006/bbrc.1996.0059. [PubMed:8573157 ]
  3. Youn BS, Kim SH, Lyu MS, Kozak CA, Taub DD, Kwon BS: Molecular cloning and characterization of a cDNA, CHEMR1, encoding a chemokine receptor with a homology to the human C-C chemokine receptor, CCR-4. Blood. 1997 Jun 15;89(12):4448-60. [PubMed:9192769 ]
  4. Chvatchko Y, Hoogewerf AJ, Meyer A, Alouani S, Juillard P, Buser R, Conquet F, Proudfoot AE, Wells TN, Power CA: A key role for CC chemokine receptor 4 in lipopolysaccharide-induced endotoxic shock. J Exp Med. 2000 May 15;191(10):1755-64. doi: 10.1084/jem.191.10.1755. [PubMed:10811868 ]