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Identification
HMDB Protein ID HMDBP13781
Secondary Accession Numbers None
Name BRISC and BRCA1-A complex member 1
Synonyms
  1. Mediator of RAP80 interactions and targeting subunit of 40 kDa
  2. New component of the BRCA1-A complex
Gene Name BABAM1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:24075985, PubMed:26195665). In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985).
Pathways
  • Homologous recombination
Reactions Not Available
GO Classification
Biological Process
cell cycle
protein deubiquitination
cell division
chromatin organization
double-strand break repair via nonhomologous end joining
response to ionizing radiation
double-strand break repair
protein K63-linked deubiquitination
signal transduction involved in G2 DNA damage checkpoint
positive regulation of DNA repair
Cellular Component
cytosol
cytoplasm
nucleus
nucleoplasm
BRISC complex
BRCA1-A complex
nuclear body
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 329
Molecular Weight 36559.71
Theoretical pI 4.641
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NWV8
UniProtKB/Swiss-Prot Entry Name BABA1_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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