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Showing Protein Monocyte differentiation antigen CD14 (HMDBP13786)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13786
Secondary Accession Numbers None
Name Monocyte differentiation antigen CD14
Synonyms
  1. Myeloid cell-specific leucine-rich glycoprotein
Gene Name CD14
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS) (PubMed:16148141). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (PubMed:8612135, PubMed:15895089). Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell surface and subsequently are targeted to the Golgi in a lipid-raft dependent pathway (By similarity). Acts as an accessory receptor for M.tuberculosis lipoproteins LprA, LprG and LpqH, in conjunction with coreceptors TLR2 and TLR1. The lipoproteins act as agonists to modulate antigen presenting cell functions in response to the pathogen (PubMed:19362712). Binds electronegative LDL (LDL(-)) and mediates the cytokine release induced by LDL(-) (By similarity).
Pathways
  • Acute myeloid leukemia
  • Amoebiasis
  • Hematopoietic cell lineage
  • Legionellosis
  • Lipid and atherosclerosis
  • MAPK signaling pathway
  • NF-kappa B signaling pathway
  • Pertussis
  • Phagosome
  • Salmonella infection
  • Toll-like receptor signaling pathway
  • Transcriptional misregulation in cancer
  • Tuberculosis
Reactions Not Available
GO Classification
Biological Process
cellular response to lipoteichoic acid
cellular response to triacyl bacterial lipopeptide
positive regulation of interleukin-8 production
response to electrical stimulus
response to heat
response to bacterium
inflammatory response
response to magnesium ion
positive regulation of cytokine production
response to ethanol
cellular response to lipopolysaccharide
cellular response to molecule of bacterial origin
positive regulation of endocytosis
innate immune response
response to tumor necrosis factor
positive regulation of interferon-gamma production
positive regulation of tumor necrosis factor production
response to molecule of bacterial origin
cellular response to diacyl bacterial lipopeptide
lipopolysaccharide-mediated signaling pathway
toll-like receptor 4 signaling pathway
receptor-mediated endocytosis
positive regulation of type I interferon production
positive regulation of NIK/NF-kappaB signaling
Cellular Component
cell surface
membrane raft
plasma membrane
Golgi apparatus
lipopolysaccharide receptor complex
extracellular space
anchored to external side of plasma membrane
external side of plasma membrane
Molecular Function
lipopolysaccharide binding
lipoteichoic acid binding
lipopeptide binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 366
Molecular Weight 39203.385
Theoretical pI 5.213
Pfam Domain Function Not Available
Signals
  • 1-15;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P10810
UniProtKB/Swiss-Prot Entry Name CD14_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Drage MG, Pecora ND, Hise AG, Febbraio M, Silverstein RL, Golenbock DT, Boom WH, Harding CV: TLR2 and its co-receptors determine responses of macrophages and dendritic cells to lipoproteins of Mycobacterium tuberculosis. Cell Immunol. 2009;258(1):29-37. doi: 10.1016/j.cellimm.2009.03.008. Epub 2009 Apr 11. [PubMed:19362712 ]
  3. Setoguchi M, Nasu N, Yoshida S, Higuchi Y, Akizuki S, Yamamoto S: Mouse and human CD14 (myeloid cell-specific leucine-rich glycoprotein) primary structure deduced from cDNA clones. Biochim Biophys Acta. 1989 Jul 7;1008(2):213-22. doi: 10.1016/0167-4781(80)90012-3. [PubMed:2472171 ]
  4. Haziot A, Ferrero E, Kontgen F, Hijiya N, Yamamoto S, Silver J, Stewart CL, Goyert SM: Resistance to endotoxin shock and reduced dissemination of gram-negative bacteria in CD14-deficient mice. Immunity. 1996 Apr;4(4):407-14. doi: 10.1016/s1074-7613(00)80254-x. [PubMed:8612135 ]
  5. Matsuura K, Setoguchi M, Nasu N, Higuchi Y, Yoshida S, Akizuki S, Yamamoto S: Nucleotide and amino acid sequences of the mouse CD14 gene. Nucleic Acids Res. 1989 Mar 11;17(5):2132. doi: 10.1093/nar/17.5.2132. [PubMed:2467257 ]
  6. Ferrero E, Hsieh CL, Francke U, Goyert SM: CD14 is a member of the family of leucine-rich proteins and is encoded by a gene syntenic with multiple receptor genes. J Immunol. 1990 Jul 1;145(1):331-6. [PubMed:1694207 ]
  7. Gangloff SC, Zahringer U, Blondin C, Guenounou M, Silver J, Goyert SM: Influence of CD14 on ligand interactions between lipopolysaccharide and its receptor complex. J Immunol. 2005 Sep 15;175(6):3940-5. doi: 10.4049/jimmunol.175.6.3940. [PubMed:16148141 ]
  8. Jiang Z, Georgel P, Du X, Shamel L, Sovath S, Mudd S, Huber M, Kalis C, Keck S, Galanos C, Freudenberg M, Beutler B: CD14 is required for MyD88-independent LPS signaling. Nat Immunol. 2005 Jun;6(6):565-70. doi: 10.1038/ni1207. Epub 2005 May 15. [PubMed:15895089 ]
  9. Zhao J, He D, Su Y, Berdyshev E, Chun J, Natarajan V, Zhao Y: Lysophosphatidic acid receptor 1 modulates lipopolysaccharide-induced inflammation in alveolar epithelial cells and murine lungs. Am J Physiol Lung Cell Mol Physiol. 2011 Oct;301(4):L547-56. doi: 10.1152/ajplung.00058.2011. Epub 2011 Aug 5. [PubMed:21821728 ]
  10. Tanimura N, Saitoh S, Ohto U, Akashi-Takamura S, Fujimoto Y, Fukase K, Shimizu T, Miyake K: The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014 Jun;26(6):307-14. doi: 10.1093/intimm/dxt071. Epub 2013 Dec 31. [PubMed:24380872 ]
  11. Kim JI, Lee CJ, Jin MS, Lee CH, Paik SG, Lee H, Lee JO: Crystal structure of CD14 and its implications for lipopolysaccharide signaling. J Biol Chem. 2005 Mar 25;280(12):11347-51. doi: 10.1074/jbc.M414607200. Epub 2005 Jan 10. [PubMed:15644310 ]