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Showing Protein Interferon regulatory factor 7 (HMDBP13795)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13795
Secondary Accession Numbers None
Name Interferon regulatory factor 7
Synonyms
  1. IRF-7
Gene Name IRF7
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Key transcriptional regulator of type I interferon (IFN)-dependent immune responses and plays a critical role in the innate immune response against DNA and RNA viruses. Regulates the transcription of type I IFN genes (IFN-alpha and IFN-beta) and IFN-stimulated genes (ISG) by binding to an interferon-stimulated response element (ISRE) in their promoters (PubMed:17574024, PubMed:32972995). Can efficiently activate both the IFN-beta (IFNB) and the IFN-alpha (IFNA) genes and mediate their induction via both the virus-activated, MyD88-independent pathway and the TLR-activated, MyD88-dependent pathway. Induces transcription of ubiquitin hydrolase USP25 mRNA in response to lipopolysaccharide (LPS) or viral infection in a type I IFN-dependent manner (By similarity). Required during both the early and late phases of the IFN gene induction but is more critical for the late than for the early phase. Exists in an inactive form in the cytoplasm of uninfected cells and following viral infection, double-stranded RNA (dsRNA), or toll-like receptor (TLR) signaling, becomes phosphorylated by IKBKE and TBK1 kinases. This induces a conformational change, leading to its dimerization and nuclear localization where along with other coactivators it can activate transcription of the type I IFN and ISG genes. Can also play a role in regulating adaptive immune responses by inducing PSMB9/LMP2 expression, either directly or through induction of IRF1. Binds to the Q promoter (Qp) of EBV nuclear antigen 1 a (EBNA1) and may play a role in the regulation of EBV latency. Can activate distinct gene expression programs in macrophages and regulate the anti-tumor properties of primary macrophages (By similarity) (PubMed:11073981, PubMed:12374802, PubMed:15361868, PubMed:17404045).
Pathways
  • Cytosolic DNA-sensing pathway
  • Epstein-Barr virus infection
  • Hepatitis B
  • Hepatitis C
  • Herpes simplex virus 1 infection
  • Influenza A
  • Kaposi sarcoma-associated herpesvirus infection
  • Lipid and atherosclerosis
  • Measles
  • NOD-like receptor signaling pathway
  • RIG-I-like receptor signaling pathway
  • Toll-like receptor signaling pathway
  • Viral carcinogenesis
Reactions Not Available
GO Classification
Biological Process
regulation of type I interferon production
response to DNA damage stimulus
interferon-gamma-mediated signaling pathway
response to virus
type I interferon-mediated signaling pathway
positive regulation of interferon-beta production
regulation of transcription from RNA polymerase II promoter
positive regulation of interferon-alpha production
defense response to virus
innate immune response
positive regulation of transcription, DNA-dependent
negative regulation of transcription from RNA polymerase II promoter
positive regulation of transcription from RNA polymerase II promoter
regulation of adaptive immune response
immunoglobulin mediated immune response
immune system process
TRIF-dependent toll-like receptor signaling pathway
establishment of viral latency
MDA-5 signaling pathway
negative regulation of macrophage apoptotic process
positive regulation of type I interferon-mediated signaling pathway
regulation of immune response
regulation of monocyte differentiation
regulation of MyD88-dependent toll-like receptor signaling pathway
regulation of MyD88-independent toll-like receptor signaling pathway
positive regulation of type I interferon production
Cellular Component
cytosol
cytoplasm
nucleus
nucleoplasm
chromatin
endosome membrane
Molecular Function
DNA-binding transcription factor activity, RNA polymerase II-specific
RNA polymerase II core promoter proximal region sequence-specific DNA binding
sequence-specific double-stranded DNA binding
DNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 503
Molecular Weight 54276.99
Theoretical pI 6.261
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q92985
UniProtKB/Swiss-Prot Entry Name IRF7_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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