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Showing Protein BRISC and BRCA1-A complex member 2 (HMDBP13806)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13806
Secondary Accession Numbers None
Name BRISC and BRCA1-A complex member 2
Synonyms
  1. BRCA1-A complex subunit BRE
  2. BRCA1/BRCA2-containing complex subunit 45
  3. Brain and reproductive organ-expressed protein
Gene Name BABAM2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX (PubMed:17525341, PubMed:19261746, PubMed:19261749, PubMed:19261748). In the BRCA1-A complex, it acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity and modulating the E3 ubiquitin ligase activity of the BRCA1-BARD1 heterodimer (PubMed:21282113, PubMed:19261748). Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates (PubMed:19214193, PubMed:24075985, PubMed:25283148, PubMed:26195665). Within the BRISC complex, acts as an adapter that bridges the interaction between BABAM1/NBA1 and the rest of the complex, thereby being required for the complex integrity (PubMed:21282113). The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). The BRISC complex plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression (PubMed:24075985). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway. May regulate TNF-alpha signaling through its interactions with TNFRSF1A; however these effects may be indirect (PubMed:15465831).
Pathways
  • Homologous recombination
Reactions Not Available
GO Classification
Biological Process
signal transduction
cell cycle
protein deubiquitination
cell division
chromatin organization
double-strand break repair via nonhomologous end joining
apoptotic process
negative regulation of apoptotic process
response to ionizing radiation
double-strand break repair
response to DNA damage stimulus
protein K63-linked deubiquitination
signal transduction involved in G2 DNA damage checkpoint
positive regulation of DNA repair
Cellular Component
cytosol
cytoplasm
nucleus
nucleoplasm
BRISC complex
BRCA1-A complex
nuclear ubiquitin ligase complex
Molecular Function
peroxisome targeting sequence binding
tumor necrosis factor receptor binding
polyubiquitin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 383
Molecular Weight 43551.31
Theoretical pI 5.814
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9NXR7
UniProtKB/Swiss-Prot Entry Name BABA2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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