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Showing Protein BRISC complex subunit Abraxas 2 (HMDBP13808)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13808
Secondary Accession Numbers None
Name BRISC complex subunit Abraxas 2
Synonyms
  1. Abraxas brother protein 1
  2. Protein FAM175B
Gene Name ABRAXAS2
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked polyubiquitin, leaving the last ubiquitin chain attached to its substrates (PubMed:19214193, PubMed:20032457, PubMed:20656690, PubMed:24075985). May act as a central scaffold protein that assembles the various components of the BRISC complex and retains them in the cytoplasm (PubMed:20656690). Plays a role in regulating the onset of apoptosis via its role in modulating 'Lys-63'-linked ubiquitination of target proteins (By similarity). Required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 (PubMed:26195665). Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activities by enhancing its stability and cell surface expression (PubMed:24075985, PubMed:26344097). Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination (PubMed:24075985). Required for normal induction of p53/TP53 in response to DNA damage (PubMed:25283148). Independent of the BRISC complex, promotes interaction between USP7 and p53/TP53, and thereby promotes deubiquitination of p53/TP53, preventing its degradation and resulting in increased p53/TP53-mediated transcription regulation and p53/TP53-dependent apoptosis in response to DNA damage (PubMed:25283148).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
protein deubiquitination
cell division
chromosome segregation
attachment of spindle microtubules to kinetochore
mitotic cell cycle
mitotic spindle assembly
protein K63-linked deubiquitination
response to ischemia
Cellular Component
cytosol
cytoplasm
nucleus
BRISC complex
spindle pole
microtubule
Molecular Function
microtubule binding
polyubiquitin binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 415
Molecular Weight 46900.42
Theoretical pI 6.219
Pfam Domain Function Not Available
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q15018
UniProtKB/Swiss-Prot Entry Name ABRX2_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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