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Identification
HMDB Protein ID HMDBP13811
Secondary Accession Numbers None
Name Tyrosine-protein kinase Lyn
Synonyms
  1. Lck/Yes-related novel protein tyrosine kinase
  2. V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  3. p53Lyn
  4. p56Lyn
Gene Name LYN
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Mediates phosphorylation of the BCR-ABL fusion protein. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-107'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (By similarity). Phosphorylates CLNK (By similarity).
Pathways
  • B cell receptor signaling pathway
  • Chemokine signaling pathway
  • Epithelial cell signaling in Helicobacter pylori infection
  • Epstein-Barr virus infection
  • Fc epsilon RI signaling pathway
  • Fc gamma R-mediated phagocytosis
  • Kaposi sarcoma-associated herpesvirus infection
  • Lipid and atherosclerosis
  • Long-term depression
  • NF-kappa B signaling pathway
  • Platelet activation
  • Viral carcinogenesis
Reactions Not Available
GO Classification
Biological Process
signal transduction
positive regulation of mast cell proliferation
negative regulation of inflammatory response to antigenic stimulus
regulation of cytokine production
B cell receptor signaling pathway
platelet activation
platelet degranulation
B cell homeostasis
negative regulation of MAP kinase activity
dendritic cell differentiation
Fc receptor mediated inhibitory signaling pathway
cellular response to extracellular stimulus
Fc receptor mediated stimulatory signaling pathway
positive regulation of cell migration
Fc-epsilon receptor signaling pathway
Fc-gamma receptor signaling pathway involved in phagocytosis
histamine secretion by mast cell
response to amino acid stimulus
immune response-regulating cell surface receptor signaling pathway
negative regulation of intracellular signal transduction
negative regulation of mast cell proliferation
oligodendrocyte development
leukocyte migration
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of cell proliferation
positive regulation of dendritic cell apoptotic process
positive regulation of Fc receptor mediated stimulatory signaling pathway
response to hormone stimulus
positive regulation of oligodendrocyte progenitor proliferation
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of tyrosine phosphorylation of STAT protein
regulation of erythrocyte differentiation
regulation of mast cell degranulation
regulation of monocyte chemotaxis
negative regulation of toll-like receptor 4 signaling pathway
regulation of release of sequestered calcium ion into cytosol
response to sterol depletion
positive regulation of phosphatidylinositol 3-kinase activity
tolerance induction to self antigen
regulation of B cell apoptotic process
neuron projection development
response to insulin stimulus
response to DNA damage stimulus
response to drug
ephrin receptor signaling pathway
regulation of platelet aggregation
positive regulation of protein phosphorylation
regulation of cell adhesion mediated by integrin
T cell costimulation
JAK-STAT cascade involved in growth hormone signaling pathway
regulation of B cell receptor signaling pathway
peptidyl-tyrosine phosphorylation
regulation of ERK1 and ERK2 cascade
negative regulation of protein phosphorylation
blood coagulation
stimulatory C-type lectin receptor signaling pathway
innate immune response
positive regulation of neuron projection development
erythrocyte differentiation
regulation of mast cell activation
negative regulation of myeloid leukocyte differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
viral reproduction
response to carbohydrate stimulus
cell differentiation
positive regulation of glial cell proliferation
positive regulation of Ras protein signal transduction
adaptive immune response
protein phosphorylation
positive regulation of cellular component movement
regulation of protein phosphorylation
cellular response to retinoic acid
negative regulation of B cell proliferation
negative regulation of immune response
response to toxin
response to organic cyclic compound
negative regulation of cell proliferation
negative regulation of ERK1 and ERK2 cascade
lipopolysaccharide-mediated signaling pathway
negative regulation of toll-like receptor 2 signaling pathway
protein autophosphorylation
positive regulation of phosphatidylinositol 3-kinase cascade
toll-like receptor 4 signaling pathway
response to axon injury
intracellular signal transduction
cellular response to heat
Cellular Component
cytosol
membrane raft
integrin alpha2-beta1 complex
postsynaptic specialization, intracellular component
cytoplasm
mitochondrial crista
extracellular vesicular exosome
plasma membrane
Golgi apparatus
perinuclear region of cytoplasm
nucleus
adherens junction
glutamatergic synapse
postsynaptic density
intracellular membrane-bounded organelle
extrinsic to internal side of plasma membrane
mitochondrial intermembrane space
Molecular Function
gamma-tubulin binding
glycosphingolipid binding
phosphorylation-dependent protein binding
transmembrane receptor protein tyrosine kinase activity
kinase activity
platelet-derived growth factor receptor binding
protein tyrosine kinase activity
ATP binding
ubiquitin protein ligase binding
ion channel binding
receptor binding
SH3 domain binding
integrin binding
enzyme binding
non-membrane spanning protein tyrosine kinase activity
ephrin receptor binding
phosphoprotein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 512
Molecular Weight 58573.595
Theoretical pI 7.111
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P07948
UniProtKB/Swiss-Prot Entry Name LYN_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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