Hmdb loader

Showing Protein Tyrosine-protein kinase Lyn (HMDBP13813)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13813
Secondary Accession Numbers None
Name Tyrosine-protein kinase Lyn
Synonyms
  1. V-yes-1 Yamaguchi sarcoma viral related oncogene homolog
  2. p53Lyn
  3. p56Lyn
Gene Name LYN
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Non-receptor tyrosine-protein kinase that transmits signals from cell surface receptors and plays an important role in the regulation of innate and adaptive immune responses, hematopoiesis, responses to growth factors and cytokines, integrin signaling, but also responses to DNA damage and genotoxic agents. Functions primarily as negative regulator, but can also function as activator, depending on the context. Required for the initiation of the B-cell response, but also for its down-regulation and termination. Plays an important role in the regulation of B-cell differentiation, proliferation, survival and apoptosis, and is important for immune self-tolerance. Acts downstream of several immune receptors, including the B-cell receptor, CD79A, CD79B, CD5, CD19, CD22, FCER1, FCGR2, FCGR1A, TLR2 and TLR4. Plays a role in the inflammatory response to bacterial lipopolysaccharide. Mediates the responses to cytokines and growth factors in hematopoietic progenitors, platelets, erythrocytes, and in mature myeloid cells, such as dendritic cells, neutrophils and eosinophils. Acts downstream of EPOR, KIT, MPL, the chemokine receptor CXCR4, as well as the receptors for IL3, IL5 and CSF2. Plays an important role in integrin signaling. Regulates cell proliferation, survival, differentiation, migration, adhesion, degranulation, and cytokine release. Down-regulates signaling pathways by phosphorylation of immunoreceptor tyrosine-based inhibitory motifs (ITIM), that then serve as binding sites for phosphatases, such as PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1, that modulate signaling by dephosphorylation of kinases and their substrates. Phosphorylates LIME1 in response to CD22 activation. Phosphorylates BTK, CBL, CD5, CD19, CD72, CD79A, CD79B, CSF2RB, DOK1, HCLS1, LILRB3/PIR-B, MS4A2/FCER1B, SYK and TEC. Promotes phosphorylation of SIRPA, PTPN6/SHP-1, PTPN11/SHP-2 and INPP5D/SHIP-1. Required for rapid phosphorylation of FER in response to FCER1 activation. Mediates KIT phosphorylation. Acts as an effector of EPOR (erythropoietin receptor) in controlling KIT expression and may play a role in erythroid differentiation during the switch between proliferation and maturation. Depending on the context, activates or inhibits several signaling cascades. Regulates phosphatidylinositol 3-kinase activity and AKT1 activation. Regulates activation of the MAP kinase signaling cascade, including activation of MAP2K1/MEK1, MAPK1/ERK2, MAPK3/ERK1, MAPK8/JNK1 and MAPK9/JNK2. Mediates activation of STAT5A and/or STAT5B. Phosphorylates LPXN on 'Tyr-72'. Kinase activity facilitates TLR4-TLR6 heterodimerization and signal initiation. Phosphorylates SCIMP on 'Tyr-96'; this enhances binding of SCIMP to TLR4, promoting the phosphorylation of TLR4, and a selective cytokine response to lipopolysaccharide in macrophages (PubMed:28098138). Phosphorylates CLNK (PubMed:12681493).
Pathways
  • B cell receptor signaling pathway
  • Chemokine signaling pathway
  • Epstein-Barr virus infection
  • Fc epsilon RI signaling pathway
  • Fc gamma R-mediated phagocytosis
  • Kaposi sarcoma-associated herpesvirus infection
  • Lipid and atherosclerosis
  • Long-term depression
  • NF-kappa B signaling pathway
  • Platelet activation
  • Viral carcinogenesis
Reactions Not Available
GO Classification
Biological Process
signal transduction
positive regulation of mast cell proliferation
regulation of cytokine production
B cell receptor signaling pathway
regulation of inflammatory response
platelet degranulation
B cell homeostasis
negative regulation of MAP kinase activity
dendritic cell differentiation
Fc receptor mediated inhibitory signaling pathway
cellular response to extracellular stimulus
Fc receptor mediated stimulatory signaling pathway
positive regulation of cell migration
histamine secretion by mast cell
response to amino acid stimulus
immune response-regulating cell surface receptor signaling pathway
positive regulation of phosphorylation
negative regulation of intracellular signal transduction
negative regulation of mast cell proliferation
oligodendrocyte development
positive regulation of aspartic-type endopeptidase activity involved in amyloid precursor protein catabolic process
positive regulation of cell proliferation
positive regulation of dendritic cell apoptotic process
positive regulation of Fc receptor mediated stimulatory signaling pathway
response to hormone stimulus
positive regulation of oligodendrocyte progenitor proliferation
positive regulation of stress-activated protein kinase signaling cascade
positive regulation of tyrosine phosphorylation of STAT protein
regulation of erythrocyte differentiation
regulation of mast cell degranulation
regulation of monocyte chemotaxis
negative regulation of toll-like receptor 4 signaling pathway
regulation of release of sequestered calcium ion into cytosol
response to sterol depletion
positive regulation of phosphatidylinositol 3-kinase activity
tolerance induction to self antigen
regulation of B cell apoptotic process
neuron projection development
response to insulin stimulus
response to DNA damage stimulus
response to drug
regulation of platelet aggregation
positive regulation of protein phosphorylation
regulation of cell adhesion mediated by integrin
hemopoiesis
regulation of B cell receptor signaling pathway
peptidyl-tyrosine phosphorylation
regulation of ERK1 and ERK2 cascade
negative regulation of protein phosphorylation
innate immune response
positive regulation of neuron projection development
erythrocyte differentiation
regulation of mast cell activation
hemoglobin biosynthetic process
negative regulation of myeloid leukocyte differentiation
transmembrane receptor protein tyrosine kinase signaling pathway
response to carbohydrate stimulus
cell differentiation
positive regulation of glial cell proliferation
adaptive immune response
protein phosphorylation
positive regulation of cellular component movement
cellular response to retinoic acid
negative regulation of B cell proliferation
response to toxin
response to organic cyclic compound
negative regulation of cell proliferation
negative regulation of ERK1 and ERK2 cascade
lipopolysaccharide-mediated signaling pathway
negative regulation of toll-like receptor 2 signaling pathway
protein autophosphorylation
toll-like receptor 4 signaling pathway
response to axon injury
intracellular signal transduction
cellular response to heat
Cellular Component
cytosol
mitochondrial membrane
membrane raft
integrin alpha2-beta1 complex
postsynaptic specialization, intracellular component
protein-containing complex
cytoplasm
mitochondrial crista
plasma membrane
Golgi apparatus
perinuclear region of cytoplasm
nucleus
adherens junction
glutamatergic synapse
membrane
postsynaptic density
intracellular membrane-bounded organelle
extrinsic to internal side of plasma membrane
mitochondrial intermembrane space
Molecular Function
gamma-tubulin binding
glycosphingolipid binding
phosphorylation-dependent protein binding
protein-containing complex binding
transmembrane receptor protein tyrosine kinase activity
erythropoietin receptor binding
platelet-derived growth factor receptor binding
protein tyrosine kinase activity
ATP binding
ubiquitin protein ligase binding
ion channel binding
receptor binding
SH3 domain binding
integrin binding
protein kinase activity
enzyme binding
non-membrane spanning protein tyrosine kinase activity
ephrin receptor binding
phosphoprotein binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 512
Molecular Weight 58811.795
Theoretical pI 7.157
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P25911
UniProtKB/Swiss-Prot Entry Name LYN_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Grishin AV, Azhipa O, Semenov I, Corey SJ: Interaction between growth arrest-DNA damage protein 34 and Src kinase Lyn negatively regulates genotoxic apoptosis. Proc Natl Acad Sci U S A. 2001 Aug 28;98(18):10172-7. Epub 2001 Aug 21. [PubMed:11517336 ]
  3. Rathore VB, Okada M, Newman PJ, Newman DK: Paxillin family members function as Csk-binding proteins that regulate Lyn activity in human and murine platelets. Biochem J. 2007 Apr 15;403(2):275-81. [PubMed:17233630 ]
  4. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  5. Trost M, English L, Lemieux S, Courcelles M, Desjardins M, Thibault P: The phagosomal proteome in interferon-gamma-activated macrophages. Immunity. 2009 Jan 16;30(1):143-54. doi: 10.1016/j.immuni.2008.11.006. [PubMed:19144319 ]
  6. Lu R, Pan H, Shively JE: CEACAM1 negatively regulates IL-1beta production in LPS activated neutrophils by recruiting SHP-1 to a SYK-TLR4-CEACAM1 complex. PLoS Pathog. 2012;8(4):e1002597. doi: 10.1371/journal.ppat.1002597. Epub 2012 Apr 5. [PubMed:22496641 ]
  7. Ballif BA, Carey GR, Sunyaev SR, Gygi SP: Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain. J Proteome Res. 2008 Jan;7(1):311-8. doi: 10.1021/pr0701254. Epub 2007 Nov 23. [PubMed:18034455 ]
  8. Ahn E, Lee H, Yun Y: LIME acts as a transmembrane adapter mediating BCR-dependent B-cell activation. Blood. 2006 Feb 15;107(4):1521-7. doi: 10.1182/blood-2005-05-1859. Epub 2005 Oct 25. [PubMed:16249387 ]
  9. Peirce MJ, Brook M, Morrice N, Snelgrove R, Begum S, Lanfrancotti A, Notley C, Hussell T, Cope AP, Wait R: Themis2/ICB1 is a signaling scaffold that selectively regulates macrophage Toll-like receptor signaling and cytokine production. PLoS One. 2010 Jul 13;5(7):e11465. doi: 10.1371/journal.pone.0011465. [PubMed:20644716 ]
  10. Luo L, Bokil NJ, Wall AA, Kapetanovic R, Lansdaal NM, Marceline F, Burgess BJ, Tong SJ, Guo Z, Alexandrov K, Ross IL, Hibbs ML, Stow JL, Sweet MJ: SCIMP is a transmembrane non-TIR TLR adaptor that promotes proinflammatory cytokine production from macrophages. Nat Commun. 2017 Jan 18;8:14133. doi: 10.1038/ncomms14133. [PubMed:28098138 ]
  11. Lannutti BJ, Drachman JG: Lyn tyrosine kinase regulates thrombopoietin-induced proliferation of hematopoietic cell lines and primary megakaryocytic progenitors. Blood. 2004 May 15;103(10):3736-43. doi: 10.1182/blood-2003-10-3566. Epub 2004 Jan 15. [PubMed:14726379 ]
  12. Chew V, Lam KP: Leupaxin negatively regulates B cell receptor signaling. J Biol Chem. 2007 Sep 14;282(37):27181-27191. doi: 10.1074/jbc.M704625200. Epub 2007 Jul 19. [PubMed:17640867 ]
  13. Lowell CA: Src-family kinases: rheostats of immune cell signaling. Mol Immunol. 2004 Jul;41(6-7):631-43. doi: 10.1016/j.molimm.2004.04.010. [PubMed:15220000 ]
  14. Gauld SB, Cambier JC: Src-family kinases in B-cell development and signaling. Oncogene. 2004 Oct 18;23(48):8001-6. doi: 10.1038/sj.onc.1208075. [PubMed:15489917 ]
  15. Xu Y, Harder KW, Huntington ND, Hibbs ML, Tarlinton DM: Lyn tyrosine kinase: accentuating the positive and the negative. Immunity. 2005 Jan;22(1):9-18. doi: 10.1016/j.immuni.2004.12.004. [PubMed:15664155 ]
  16. Stanley E, Ralph S, McEwen S, Boulet I, Holtzman DA, Lock P, Dunn AR: Alternatively spliced murine lyn mRNAs encode distinct proteins. Mol Cell Biol. 1991 Jul;11(7):3399-406. doi: 10.1128/mcb.11.7.3399-3406.1991. [PubMed:1710766 ]
  17. Yi TL, Bolen JB, Ihle JN: Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol Cell Biol. 1991 May;11(5):2391-8. doi: 10.1128/mcb.11.5.2391-2398.1991. [PubMed:2017160 ]
  18. Wilks AF, Kurban RR, Hovens CM, Ralph SJ: The application of the polymerase chain reaction to cloning members of the protein tyrosine kinase family. Gene. 1989 Dec 21;85(1):67-74. doi: 10.1016/0378-1119(89)90465-4. [PubMed:2482828 ]
  19. Yamanashi Y, Kakiuchi T, Mizuguchi J, Yamamoto T, Toyoshima K: Association of B cell antigen receptor with protein tyrosine kinase Lyn. Science. 1991 Jan 11;251(4990):192-4. doi: 10.1126/science.1702903. [PubMed:1702903 ]
  20. Clark MR, Johnson SA, Cambier JC: Analysis of Ig-alpha-tyrosine kinase interaction reveals two levels of binding specificity and tyrosine phosphorylated Ig-alpha stimulation of Fyn activity. EMBO J. 1994 Apr 15;13(8):1911-9. [PubMed:8168489 ]
  21. Law DA, Chan VW, Datta SK, DeFranco AL: B-cell antigen receptor motifs have redundant signalling capabilities and bind the tyrosine kinases PTK72, Lyn and Fyn. Curr Biol. 1993 Oct 1;3(10):645-57. doi: 10.1016/0960-9822(93)90062-s. [PubMed:15335855 ]
  22. Kurosaki T, Takata M, Yamanashi Y, Inazu T, Taniguchi T, Yamamoto T, Yamamura H: Syk activation by the Src-family tyrosine kinase in the B cell receptor signaling. J Exp Med. 1994 May 1;179(5):1725-9. doi: 10.1084/jem.179.5.1725. [PubMed:7513017 ]
  23. Pleiman CM, Abrams C, Gauen LT, Bedzyk W, Jongstra J, Shaw AS, Cambier JC: Distinct p53/56lyn and p59fyn domains associate with nonphosphorylated and phosphorylated Ig-alpha. Proc Natl Acad Sci U S A. 1994 May 10;91(10):4268-72. doi: 10.1073/pnas.91.10.4268. [PubMed:8183901 ]
  24. Hibbs ML, Tarlinton DM, Armes J, Grail D, Hodgson G, Maglitto R, Stacker SA, Dunn AR: Multiple defects in the immune system of Lyn-deficient mice, culminating in autoimmune disease. Cell. 1995 Oct 20;83(2):301-11. doi: 10.1016/0092-8674(95)90171-x. [PubMed:7585947 ]
  25. Nishizumi H, Taniuchi I, Yamanashi Y, Kitamura D, Ilic D, Mori S, Watanabe T, Yamamoto T: Impaired proliferation of peripheral B cells and indication of autoimmune disease in lyn-deficient mice. Immunity. 1995 Nov;3(5):549-60. doi: 10.1016/1074-7613(95)90126-4. [PubMed:7584145 ]
  26. Tanaka S, Neff L, Baron R, Levy JB: Tyrosine phosphorylation and translocation of the c-cbl protein after activation of tyrosine kinase signaling pathways. J Biol Chem. 1995 Jun 16;270(24):14347-51. doi: 10.1074/jbc.270.24.14347. [PubMed:7782294 ]
  27. Sotirellis N, Johnson TM, Hibbs ML, Stanley IJ, Stanley E, Dunn AR, Cheng HC: Autophosphorylation induces autoactivation and a decrease in the Src homology 2 domain accessibility of the Lyn protein kinase. J Biol Chem. 1995 Dec 15;270(50):29773-80. doi: 10.1074/jbc.270.50.29773. [PubMed:8530369 ]
  28. Mano H, Yamashita Y, Miyazato A, Miura Y, Ozawa K: Tec protein-tyrosine kinase is an effector molecule of Lyn protein-tyrosine kinase. FASEB J. 1996 Apr;10(5):637-42. doi: 10.1096/fasebj.10.5.8621063. [PubMed:8621063 ]
  29. Wang J, Koizumi T, Watanabe T: Altered antigen receptor signaling and impaired Fas-mediated apoptosis of B cells in Lyn-deficient mice. J Exp Med. 1996 Sep 1;184(3):831-8. doi: 10.1084/jem.184.3.831. [PubMed:9064343 ]
  30. Rawlings DJ, Scharenberg AM, Park H, Wahl MI, Lin S, Kato RM, Fluckiger AC, Witte ON, Kinet JP: Activation of BTK by a phosphorylation mechanism initiated by SRC family kinases. Science. 1996 Feb 9;271(5250):822-5. doi: 10.1126/science.271.5250.822. [PubMed:8629002 ]
  31. Chan VW, Meng F, Soriano P, DeFranco AL, Lowell CA: Characterization of the B lymphocyte populations in Lyn-deficient mice and the role of Lyn in signal initiation and down-regulation. Immunity. 1997 Jul;7(1):69-81. doi: 10.1016/s1074-7613(00)80511-7. [PubMed:9252121 ]
  32. Nishizumi H, Yamamoto T: Impaired tyrosine phosphorylation and Ca2+ mobilization, but not degranulation, in lyn-deficient bone marrow-derived mast cells. J Immunol. 1997 Mar 1;158(5):2350-5. [PubMed:9036984 ]
  33. Chan VW, Lowell CA, DeFranco AL: Defective negative regulation of antigen receptor signaling in Lyn-deficient B lymphocytes. Curr Biol. 1998 May 7;8(10):545-53. doi: 10.1016/s0960-9822(98)70223-4. [PubMed:9601638 ]
  34. Smith KG, Tarlinton DM, Doody GM, Hibbs ML, Fearon DT: Inhibition of the B cell by CD22: a requirement for Lyn. J Exp Med. 1998 Mar 2;187(5):807-11. doi: 10.1084/jem.187.5.807. [PubMed:9480991 ]
  35. Nishizumi H, Horikawa K, Mlinaric-Rascan I, Yamamoto T: A double-edged kinase Lyn: a positive and negative regulator for antigen receptor-mediated signals. J Exp Med. 1998 Apr 20;187(8):1343-8. doi: 10.1084/jem.187.8.1343. [PubMed:9547345 ]
  36. Adachi T, Flaswinkel H, Yakura H, Reth M, Tsubata T: The B cell surface protein CD72 recruits the tyrosine phosphatase SHP-1 upon tyrosine phosphorylation. J Immunol. 1998 May 15;160(10):4662-5. [PubMed:9590210 ]
  37. Ochi H, Takeshita H, Suda T, Nisitani S, Honjo T, Watanabe T: Regulation of B-1 cell activation and its autoantibody production by Lyn kinase-regulated signallings. Immunology. 1999 Dec;98(4):595-603. doi: 10.1046/j.1365-2567.1999.00899.x. [PubMed:10594694 ]
  38. Katagiri T, Ogimoto M, Hasegawa K, Arimura Y, Mitomo K, Okada M, Clark MR, Mizuno K, Yakura H: CD45 negatively regulates lyn activity by dephosphorylating both positive and negative regulatory tyrosine residues in immature B cells. J Immunol. 1999 Aug 1;163(3):1321-6. [PubMed:10415030 ]
  39. Maeda A, Scharenberg AM, Tsukada S, Bolen JB, Kinet JP, Kurosaki T: Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene. 1999 Apr 8;18(14):2291-7. doi: 10.1038/sj.onc.1202552. [PubMed:10327049 ]
  40. Dahl ME, Arai KI, Watanabe S: Association of Lyn tyrosine kinase to the GM-CSF and IL-3 receptor common betac subunit and role of Src tyrosine kinases in DNA synthesis and anti-apoptosis. Genes Cells. 2000 Feb;5(2):143-53. doi: 10.1046/j.1365-2443.2000.00312.x. [PubMed:10672044 ]
  41. Yamanashi Y, Tamura T, Kanamori T, Yamane H, Nariuchi H, Yamamoto T, Baltimore D: Role of the rasGAP-associated docking protein p62(dok) in negative regulation of B cell receptor-mediated signaling. Genes Dev. 2000 Jan 1;14(1):11-6. [PubMed:10640270 ]
  42. Ochi H, Watanabe T: Negative regulation of B cell receptor-mediated signaling in B-1 cells through CD5 and Ly49 co-receptors via Lyn kinase activity. Int Immunol. 2000 Oct;12(10):1417-23. doi: 10.1093/intimm/12.10.1417. [PubMed:11007759 ]
  43. O'Laughlin-Bunner B, Radosevic N, Taylor ML, Shivakrupa, DeBerry C, Metcalfe DD, Zhou M, Lowell C, Linnekin D: Lyn is required for normal stem cell factor-induced proliferation and chemotaxis of primary hematopoietic cells. Blood. 2001 Jul 15;98(2):343-50. doi: 10.1182/blood.v98.2.343. [PubMed:11435302 ]
  44. Harder KW, Parsons LM, Armes J, Evans N, Kountouri N, Clark R, Quilici C, Grail D, Hodgson GS, Dunn AR, Hibbs ML: Gain- and loss-of-function Lyn mutant mice define a critical inhibitory role for Lyn in the myeloid lineage. Immunity. 2001 Oct;15(4):603-15. doi: 10.1016/s1074-7613(01)00208-4. [PubMed:11672542 ]
  45. Hibbs ML, Harder KW, Armes J, Kountouri N, Quilici C, Casagranda F, Dunn AR, Tarlinton DM: Sustained activation of Lyn tyrosine kinase in vivo leads to autoimmunity. J Exp Med. 2002 Dec 16;196(12):1593-604. doi: 10.1084/jem.20020515. [PubMed:12486102 ]
  46. Hong JJ, Yankee TM, Harrison ML, Geahlen RL: Regulation of signaling in B cells through the phosphorylation of Syk on linker region tyrosines. A mechanism for negative signaling by the Lyn tyrosine kinase. J Biol Chem. 2002 Aug 30;277(35):31703-14. doi: 10.1074/jbc.M201362200. Epub 2002 Jun 20. [PubMed:12077122 ]
  47. Fujii Y, Wakahara S, Nakao T, Hara T, Ohtake H, Komurasaki T, Kitamura K, Tatsuno A, Fujiwara N, Hozumi N, Ra C, Kitamura D, Goitsuka R: Targeting of MIST to Src-family kinases via SKAP55-SLAP-130 adaptor complex in mast cells. FEBS Lett. 2003 Apr 10;540(1-3):111-6. doi: 10.1016/s0014-5793(03)00234-5. [PubMed:12681493 ]
  48. Pereira S, Lowell C: The Lyn tyrosine kinase negatively regulates neutrophil integrin signaling. J Immunol. 2003 Aug 1;171(3):1319-27. doi: 10.4049/jimmunol.171.3.1319. [PubMed:12874221 ]
  49. Shao Y, Yang C, Elly C, Liu YC: Differential regulation of the B cell receptor-mediated signaling by the E3 ubiquitin ligase Cbl. J Biol Chem. 2004 Oct 15;279(42):43646-53. doi: 10.1074/jbc.M404082200. Epub 2004 Aug 10. [PubMed:15304502 ]
  50. Hernandez-Hansen V, Mackay GA, Lowell CA, Wilson BS, Oliver JM: The Src kinase Lyn is a negative regulator of mast cell proliferation. J Leukoc Biol. 2004 Jan;75(1):143-51. doi: 10.1189/jlb.0503224. Epub 2003 Oct 2. [PubMed:14525964 ]
  51. Beavitt SJ, Harder KW, Kemp JM, Jones J, Quilici C, Casagranda F, Lam E, Turner D, Brennan S, Sly PD, Tarlinton DM, Anderson GP, Hibbs ML: Lyn-deficient mice develop severe, persistent asthma: Lyn is a critical negative regulator of Th2 immunity. J Immunol. 2005 Aug 1;175(3):1867-75. doi: 10.4049/jimmunol.175.3.1867. [PubMed:16034130 ]
  52. Xiao W, Nishimoto H, Hong H, Kitaura J, Nunomura S, Maeda-Yamamoto M, Kawakami Y, Lowell CA, Ra C, Kawakami T: Positive and negative regulation of mast cell activation by Lyn via the FcepsilonRI. J Immunol. 2005 Nov 15;175(10):6885-92. doi: 10.4049/jimmunol.175.10.6885. [PubMed:16272347 ]
  53. Heiss E, Masson K, Sundberg C, Pedersen M, Sun J, Bengtsson S, Ronnstrand L: Identification of Y589 and Y599 in the juxtamembrane domain of Flt3 as ligand-induced autophosphorylation sites involved in binding of Src family kinases and the protein tyrosine phosphatase SHP2. Blood. 2006 Sep 1;108(5):1542-50. doi: 10.1182/blood-2005-07-008896. Epub 2006 May 9. [PubMed:16684964 ]
  54. Udell CM, Samayawardhena LA, Kawakami Y, Kawakami T, Craig AWB: Fer and Fps/Fes participate in a Lyn-dependent pathway from FcepsilonRI to platelet-endothelial cell adhesion molecule 1 to limit mast cell activation. J Biol Chem. 2006 Jul 28;281(30):20949-20957. doi: 10.1074/jbc.M604252200. Epub 2006 May 26. [PubMed:16731527 ]
  55. Samuels AL, Klinken SP, Ingley E: Liar, a novel Lyn-binding nuclear/cytoplasmic shuttling protein that influences erythropoietin-induced differentiation. Blood. 2009 Apr 16;113(16):3845-56. doi: 10.1182/blood-2008-04-153452. Epub 2008 Dec 8. [PubMed:19064729 ]
  56. Kosmider O, Buet D, Gallais I, Denis N, Moreau-Gachelin F: Erythropoietin down-regulates stem cell factor receptor (Kit) expression in the leukemic proerythroblast: role of Lyn kinase. PLoS One. 2009 May 28;4(5):e5721. doi: 10.1371/journal.pone.0005721. [PubMed:19492092 ]
  57. Li Z, Zhang G, Liu J, Stojanovic A, Ruan C, Lowell CA, Du X: An important role of the SRC family kinase Lyn in stimulating platelet granule secretion. J Biol Chem. 2010 Apr 23;285(17):12559-70. doi: 10.1074/jbc.M109.098756. Epub 2010 Feb 26. [PubMed:20189992 ]
  58. Keck S, Freudenberg M, Huber M: Activation of murine macrophages via TLR2 and TLR4 is negatively regulated by a Lyn/PI3K module and promoted by SHIP1. J Immunol. 2010 May 15;184(10):5809-18. doi: 10.4049/jimmunol.0901423. Epub 2010 Apr 12. [PubMed:20385881 ]
  59. Scapini P, Pereira S, Zhang H, Lowell CA: Multiple roles of Lyn kinase in myeloid cell signaling and function. Immunol Rev. 2009 Mar;228(1):23-40. doi: 10.1111/j.1600-065X.2008.00758.x. [PubMed:19290919 ]
  60. Williams NK, Lucet IS, Klinken SP, Ingley E, Rossjohn J: Crystal structures of the Lyn protein tyrosine kinase domain in its Apo- and inhibitor-bound state. J Biol Chem. 2009 Jan 2;284(1):284-291. doi: 10.1074/jbc.M807850200. Epub 2008 Nov 4. [PubMed:18984583 ]