Hmdb loader

Showing Protein Lipopolysaccharide-binding protein (HMDBP13837)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13837
Secondary Accession Numbers None
Name Lipopolysaccharide-binding protein
Synonyms
  1. LBP
Gene Name LBP
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed:9144073). Acts as an affinity enhancer for CD14, facilitating its association with LPS (By similarity). Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed:24380872).
Pathways
  • Lipid and atherosclerosis
  • NF-kappa B signaling pathway
  • Toll-like receptor signaling pathway
  • Tuberculosis
Reactions Not Available
GO Classification
Biological Process
positive regulation of toll-like receptor 4 signaling pathway
positive regulation of chemokine production
cellular response to lipoteichoic acid
lipopolysaccharide transport
positive regulation of interleukin-8 production
response to lipopolysaccharide
positive regulation of cytolysis
detection of molecule of bacterial origin
leukocyte chemotaxis involved in inflammatory response
macromolecule localization
opsonization
positive regulation of neutrophil chemotaxis
positive regulation of respiratory burst involved in inflammatory response
regulation of membrane permeability
negative regulation of tumor necrosis factor production
acute-phase response
cellular response to lipopolysaccharide
defense response to Gram-positive bacterium
positive regulation of phagocytosis, engulfment
innate immune response
positive regulation of tumor necrosis factor production
defense response to Gram-negative bacterium
lipopolysaccharide-mediated signaling pathway
positive regulation of interleukin-6 production
positive regulation of macrophage activation
macrophage activation involved in immune response
Cellular Component
cell surface
extracellular space
membrane
Molecular Function
lipopolysaccharide binding
receptor binding
lipoteichoic acid binding
lipopeptide binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 481
Molecular Weight 53055.01
Theoretical pI 8.503
Pfam Domain Function
Signals
  • 1-24;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q61805
UniProtKB/Swiss-Prot Entry Name LBP_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Church DM, Goodstadt L, Hillier LW, Zody MC, Goldstein S, She X, Bult CJ, Agarwala R, Cherry JL, DiCuccio M, Hlavina W, Kapustin Y, Meric P, Maglott D, Birtle Z, Marques AC, Graves T, Zhou S, Teague B, Potamousis K, Churas C, Place M, Herschleb J, Runnheim R, Forrest D, Amos-Landgraf J, Schwartz DC, Cheng Z, Lindblad-Toh K, Eichler EE, Ponting CP: Lineage-specific biology revealed by a finished genome assembly of the mouse. PLoS Biol. 2009 May 5;7(5):e1000112. doi: 10.1371/journal.pbio.1000112. Epub 2009 May 26. [PubMed:19468303 ]
  3. Tanimura N, Saitoh S, Ohto U, Akashi-Takamura S, Fujimoto Y, Fukase K, Shimizu T, Miyake K: The attenuated inflammation of MPL is due to the lack of CD14-dependent tight dimerization of the TLR4/MD2 complex at the plasma membrane. Int Immunol. 2014 Jun;26(6):307-14. doi: 10.1093/intimm/dxt071. Epub 2013 Dec 31. [PubMed:24380872 ]
  4. Lengacher S, Jongeneel CV, Le Roy D, Lee JD, Kravchenko V, Ulevitch RJ, Glauser MP, Heumann D: Reactivity of murine and human recombinant LPS-binding protein (LBP) within LPS and gram negative bacteria. J Inflamm. 1995-1996;47(4):165-72. [PubMed:9144073 ]
  5. Eckert JK, Kim YJ, Kim JI, Gurtler K, Oh DY, Sur S, Lundvall L, Hamann L, van der Ploeg A, Pickkers P, Giamarellos-Bourboulis E, Kubarenko AV, Weber AN, Kabesch M, Kumpf O, An HJ, Lee JO, Schumann RR: The crystal structure of lipopolysaccharide binding protein reveals the location of a frequent mutation that impairs innate immunity. Immunity. 2013 Oct 17;39(4):647-60. doi: 10.1016/j.immuni.2013.09.005. Epub 2013 Oct 10. [PubMed:24120359 ]