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Identification
HMDB Protein ID HMDBP13857
Secondary Accession Numbers None
Name mRNA decay activator protein ZFP36
Synonyms
  1. G0/G1 switch regulatory protein 24
  2. Growth factor-inducible nuclear protein NUP475
  3. Tristetraprolin
  4. Zinc finger protein 36
  5. Zfp-36
Gene Name ZFP36
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis (PubMed:9703499, PubMed:10330172, PubMed:10751406, PubMed:11279239, PubMed:12115244, PubMed:12748283, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:27193233, PubMed:23644599, PubMed:25815583, PubMed:31439631). Acts as an 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery (PubMed:15687258, PubMed:23644599). Recruits deadenylase CNOT7 (and probably the CCR4-NOT complex) via association with CNOT1, and hence promotes ARE-mediated mRNA deadenylation (PubMed:23644599). Functions also by recruiting components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs (PubMed:11719186, PubMed:12748283, PubMed:15687258, PubMed:16364915). Self regulates by destabilizing its own mRNA (PubMed:15187101). Binds to 3'-UTR ARE of numerous mRNAs and of its own mRNA (PubMed:10330172, PubMed:10751406, PubMed:12115244, PubMed:15187101, PubMed:15634918, PubMed:17030620, PubMed:16702957, PubMed:19188452, PubMed:20702587, PubMed:20221403, PubMed:21775632, PubMed:25815583). Plays a role in anti-inflammatory responses; suppresses tumor necrosis factor (TNF)-alpha production by stimulating ARE-mediated TNF-alpha mRNA decay and several other inflammatory ARE-containing mRNAs in interferon (IFN)- and/or lipopolysaccharide (LPS)-induced macrophages (By similarity). Plays also a role in the regulation of dendritic cell maturation at the post-transcriptional level, and hence operates as part of a negative feedback loop to limit the inflammatory response (PubMed:18367721). Promotes ARE-mediated mRNA decay of hypoxia-inducible factor HIF1A mRNA during the response of endothelial cells to hypoxia (PubMed:21775632). Positively regulates early adipogenesis of preadipocytes by promoting ARE-mediated mRNA decay of immediate early genes (IEGs) (By similarity). Negatively regulates hematopoietic/erythroid cell differentiation by promoting ARE-mediated mRNA decay of the transcription factor STAT5B mRNA (PubMed:20702587). Plays a role in maintaining skeletal muscle satellite cell quiescence by promoting ARE-mediated mRNA decay of the myogenic determination factor MYOD1 mRNA (By similarity). Associates also with and regulates the expression of non-ARE-containing target mRNAs at the post-transcriptional level, such as MHC class I mRNAs (PubMed:18367721). Participates in association with argonaute RISC catalytic components in the ARE-mediated mRNA decay mechanism; assists microRNA (miRNA) targeting ARE-containing mRNAs (PubMed:15766526). May also play a role in the regulation of cytoplasmic mRNA decapping; enhances decapping of ARE-containing RNAs, in vitro (PubMed:16364915). Involved in the delivery of target ARE-mRNAs to processing bodies (PBs) (PubMed:17369404). In addition to its cytosolic mRNA-decay function, affects nuclear pre-mRNA processing (By similarity). Negatively regulates nuclear poly(A)-binding protein PABPN1-stimulated polyadenylation activity on ARE-containing pre-mRNA during LPS-stimulated macrophages (By similarity). Also involved in the regulation of stress granule (SG) and P-body (PB) formation and fusion (By similarity). Plays a role in the regulation of keratinocyte proliferation, differentiation and apoptosis (PubMed:27182009). Plays a role as a tumor suppressor by inhibiting cell proliferation in breast cancer cells (PubMed:26926077).(Microbial infection) Negatively regulates HTLV-1 TAX-dependent transactivation of viral long terminal repeat (LTR) promoter.
Pathways
  • Human T-cell leukemia virus 1 infection
  • Kaposi sarcoma-associated herpesvirus infection
Reactions Not Available
GO Classification
Biological Process
regulation of tumor necrosis factor production
3'-UTR-mediated mRNA destabilization
nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay
regulation of mRNA stability
cellular response to fibroblast growth factor stimulus
mRNA transport
response to wounding
cellular response to tumor necrosis factor
response to starvation
cellular response to lipopolysaccharide
nuclear-transcribed mRNA poly(A) tail shortening
3'-UTR-mediated mRNA stabilization
cellular response to epidermal growth factor stimulus
miRNA mediated inhibition of translation
negative regulation of transcription from RNA polymerase II promoter
negative regulation of polynucleotide adenylyltransferase activity
negative regulation of viral transcription
negative regulation of erythrocyte differentiation
nuclear-transcribed mRNA catabolic process, deadenylation-independent decay
viral reproduction
p38MAPK cascade
positive regulation of deadenylation-independent decapping of nuclear-transcribed mRNA
positive regulation of gene silencing by miRNA
positive regulation of intracellular mRNA localization
positive regulation of nuclear-transcribed mRNA poly(A) tail shortening
regulation of keratinocyte apoptotic process
regulation of keratinocyte proliferation
MAPK cascade
cellular response to granulocyte macrophage colony-stimulating factor stimulus
cellular response to glucocorticoid stimulus
positive regulation of fat cell differentiation
negative regulation of interleukin-2 production
mRNA catabolic process
regulation of keratinocyte differentiation
Cellular Component
cytosol
cytoplasmic mRNA processing body
cytoplasm
nucleus
cytoplasmic stress granule
ribonucleoprotein complex
Molecular Function
protein kinase binding
mRNA 3'-UTR AU-rich region binding
protein-containing complex binding
metal ion binding
heat shock protein binding
RNA binding
RNA polymerase binding
14-3-3 protein binding
C-C chemokine binding
enzyme binding
DNA binding
mRNA binding
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 332
Molecular Weight 34002.645
Theoretical pI 8.624
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P26651
UniProtKB/Swiss-Prot Entry Name TTP_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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