| Identification |
|---|
| HMDB Protein ID
| HMDBP13869 |
| Secondary Accession Numbers
| None |
| Name
| D-alanyl carrier protein |
| Synonyms
|
- DCP
- D-alanine--poly(phosphoribitol) ligase subunit 2
|
| Gene Name
| DLTC |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Carrier protein involved in the D-alanylation of lipoteichoic acid (LTA). The loading of thioester-linked D-alanine onto DltC is catalyzed by D-alanine--D-alanyl carrier protein ligase DltA. The DltC-carried D-alanyl group is further transferred to cell membrane phosphatidylglycerol (PG) by forming an ester bond, probably catalyzed by DltD. D-alanylation of LTA plays an important role in modulating the properties of the cell wall in Gram-positive bacteria, influencing the net charge of the cell wall. |
| Pathways
|
- Cationic antimicrobial peptide (CAMP) resistance
- D-Amino acid metabolism
- lipoteichoic acid biosynthesis
- Two-component system
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| cell wall organization |
| lipoteichoic acid biosynthetic process |
| Cellular Component |
| cytoplasm |
| Molecular Function |
| D-alanyl carrier activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 79 |
| Molecular Weight
| 8737.76 |
| Theoretical pI
| 3.875 |
| Pfam Domain Function
|
|
| Signals
|
Not Available
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| P0A3A1 |
| UniProtKB/Swiss-Prot Entry Name
| DLTC_STRA5 |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Tettelin H, Masignani V, Cieslewicz MJ, Eisen JA, Peterson S, Wessels MR, Paulsen IT, Nelson KE, Margarit I, Read TD, Madoff LC, Wolf AM, Beanan MJ, Brinkac LM, Daugherty SC, DeBoy RT, Durkin AS, Kolonay JF, Madupu R, Lewis MR, Radune D, Fedorova NB, Scanlan D, Khouri H, Mulligan S, Carty HA, Cline RT, Van Aken SE, Gill J, Scarselli M, Mora M, Iacobini ET, Brettoni C, Galli G, Mariani M, Vegni F, Maione D, Rinaudo D, Rappuoli R, Telford JL, Kasper DL, Grandi G, Fraser CM: Complete genome sequence and comparative genomic analysis of an emerging human pathogen, serotype V Streptococcus agalactiae. Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12391-6. doi: 10.1073/pnas.182380799. Epub 2002 Aug 28. [PubMed:12200547 ]
|
