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Identification
HMDB Protein ID HMDBP13901
Secondary Accession Numbers None
Name Regulatory-associated protein of mTOR
Synonyms
  1. Raptor
  2. p150 target of rapamycin (TOR)-scaffold protein
Gene Name RPTOR
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Involved in the control of the mammalian target of rapamycin complex 1 (mTORC1) activity which regulates cell growth and survival, and autophagy in response to nutrient and hormonal signals; functions as a scaffold for recruiting mTORC1 substrates. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Involved in ciliogenesis. mTORC1 complex in excitatory neuronal transmission is required for the prosocial behavior induced by the psychoactive substance lysergic acid diethylamide (LSD) (By similarity).
Pathways
  • AMPK signaling pathway
  • Autophagy - animal
  • Autophagy - other
  • Insulin signaling pathway
  • Longevity regulating pathway
  • Longevity regulating pathway - multiple species
  • MicroRNAs in cancer
  • mTOR signaling pathway
  • PI3K-Akt signaling pathway
  • Shigellosis
  • Thermogenesis
Reactions Not Available
GO Classification
Biological Process
regulation of cell growth
response to xenobiotic stimulus
cell cycle arrest
cellular response to amino acid stimulus
regulation of autophagy
social behavior
positive regulation of G1/S transition of mitotic cell cycle
positive regulation of peptidyl-threonine phosphorylation
positive regulation of TOR signaling
positive regulation of protein serine/threonine kinase activity
viral reproduction
positive regulation of transcription from RNA polymerase III promoter
regulation of cell size
positive regulation of cell growth
cellular response to starvation
cellular response to amino acid starvation
cellular response to leucine
cellular response to nutrient levels
regulation of macroautophagy
TOR signaling
TORC1 signaling
positive regulation of endothelial cell proliferation
positive regulation of peptidyl-serine phosphorylation
regulation of cellular response to heat
Cellular Component
cytosol
cytoplasm
dendrite
cytoplasmic stress granule
nucleoplasm
lysosome
neuronal cell body
TORC1 complex
lysosomal membrane
Molecular Function
protein kinase binding
protein-containing complex binding
14-3-3 protein binding
protein serine/threonine kinase inhibitor activity
RNA polymerase III type 1 promoter sequence-specific DNA binding
RNA polymerase III type 2 promoter sequence-specific DNA binding
RNA polymerase III type 3 promoter sequence-specific DNA binding
TFIIIC-class transcription factor complex binding
protein kinase activator activity
protein-macromolecule adaptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 1335
Molecular Weight 149036.17
Theoretical pI 6.882
Pfam Domain Function
Signals Not Available
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8N122
UniProtKB/Swiss-Prot Entry Name RPTOR_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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