Hmdb loader
Identification
HMDB Protein ID HMDBP13904
Secondary Accession Numbers None
Name 5-hydroxytryptamine receptor 2A
Synonyms
  1. 5-HT-2
  2. 5-HT-2A
  3. 5-HT2A
  4. Serotonin receptor 2A
Gene Name HTR2A
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity).
Pathways
  • Calcium signaling pathway
  • Gap junction
  • Inflammatory mediator regulation of TRP channels
  • Neuroactive ligand-receptor interaction
  • Serotonergic synapse
Reactions Not Available
GO Classification
Biological Process
behavior
Cellular Component
dendrite
caveola
presynapse
cytoplasmic vesicle
axon
integral to plasma membrane
Molecular Function
G protein-coupled serotonin receptor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 470
Molecular Weight 52675.595
Theoretical pI 7.271
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 76-99;111-132;149-171;192-215;234-254;324-345;362-383;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P50129
UniProtKB/Swiss-Prot Entry Name 5HT2A_PIG
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Ullmer C, Schmuck K, Kalkman HO, Lubbert H: Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 1995 Aug 21;370(3):215-21. [PubMed:7656980 ]
  2. Johnson MP, Baez M, Kursar JD, Nelson DL: Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence. Biochim Biophys Acta. 1995 May 24;1236(1):201-6. doi: 10.1016/0005-2736(95)00073-c. [PubMed:7794950 ]