Identification |
HMDB Protein ID
| HMDBP13904 |
Secondary Accession Numbers
| None |
Name
| 5-hydroxytryptamine receptor 2A |
Synonyms
|
- 5-HT-2
- 5-HT-2A
- 5-HT2A
- Serotonin receptor 2A
|
Gene Name
| HTR2A |
Protein Type
| Unknown |
Biological Properties |
General Function
| Not Available |
Specific Function
| G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various drugs and psychoactive substances, including mescaline, psilocybin, 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI) and lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates phospholipase C and a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and promotes the release of Ca(2+) ions from intracellular stores. Affects neural activity, perception, cognition and mood. Plays a role in the regulation of behavior, including responses to anxiogenic situations and psychoactive substances. Plays a role in intestinal smooth muscle contraction, and may play a role in arterial vasoconstriction (By similarity). |
Pathways
|
- Calcium signaling pathway
- Gap junction
- Inflammatory mediator regulation of TRP channels
- Neuroactive ligand-receptor interaction
- Serotonergic synapse
|
Reactions
| Not Available |
GO Classification
|
Biological Process |
behavior |
Cellular Component |
dendrite |
caveola |
presynapse |
cytoplasmic vesicle |
axon |
integral to plasma membrane |
Molecular Function |
G protein-coupled serotonin receptor activity |
|
Cellular Location
|
Not Available
|
Gene Properties |
Chromosome Location
| Not Available |
Locus
| Not Available |
SNPs
| Not Available |
Gene Sequence
|
Not Available
|
Protein Properties |
Number of Residues
| 470 |
Molecular Weight
| 52675.595 |
Theoretical pI
| 7.271 |
Pfam Domain Function
|
|
Signals
|
Not Available
|
Transmembrane Regions
|
- 76-99;111-132;149-171;192-215;234-254;324-345;362-383;
|
Protein Sequence
|
Not Available
|
External Links |
GenBank ID Protein
| Not Available |
UniProtKB/Swiss-Prot ID
| P50129 |
UniProtKB/Swiss-Prot Entry Name
| 5HT2A_PIG |
PDB IDs
|
Not Available |
GenBank Gene ID
| Not Available |
GeneCard ID
| Not Available |
GenAtlas ID
| Not Available |
HGNC ID
| Not Available |
References |
General References
| - Ullmer C, Schmuck K, Kalkman HO, Lubbert H: Expression of serotonin receptor mRNAs in blood vessels. FEBS Lett. 1995 Aug 21;370(3):215-21. [PubMed:7656980 ]
- Johnson MP, Baez M, Kursar JD, Nelson DL: Species differences in 5-HT2A receptors: cloned pig and rhesus monkey 5-HT2A receptors reveal conserved transmembrane homology to the human rather than rat sequence. Biochim Biophys Acta. 1995 May 24;1236(1):201-6. doi: 10.1016/0005-2736(95)00073-c. [PubMed:7794950 ]
|