Hmdb loader
Identification
HMDB Protein ID HMDBP13919
Secondary Accession Numbers None
Name Calcium-independent phospholipase A2-gamma
Synonyms
  1. Intracellular membrane-associated calcium-independent phospholipase A2 gamma
  2. Patatin-like phospholipase domain-containing protein 8
  3. iPLA2-gamma
Gene Name PNPLA8
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Calcium-independent phospholipase A2, which promotes cellular membrane hydrolysis and prostaglandin production. Catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, phosphytidylserine and to a lower extent phosphatidylcholine. Cleaves membrane phospholipids. Participates in the generation of lipid second messengers through the mobilization of arachidonic acid in response to cellular stimuli. Synthesizes 2-arachidonoyl lysophosphatidylcholine, a key branch point metabolite in eicosanoid signaling. Participates in the lipid plasticity of myocardium, plays a role in the generation of signaling metabolites and has a prominent effect on the modulaton of energy storage and utilization (By similarity). Calcium-independent phospholipase A2, which catalyzes the hydrolysis of the sn-2 position of glycerophospholipids, PtdSer and to a lower extent PtdCho. Essential for maintaining efficient bioenergetic mitochondrial function through tailoring mitochondrial membrane lipid metabolism and composition (PubMed:17923475).
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
phosphatidylcholine catabolic process
fatty acid metabolic process
arachidonic acid secretion
phosphatidylethanolamine catabolic process
triglyceride homeostasis
linoleic acid metabolic process
arachidonic acid metabolic process
lipid homeostasis
prostaglandin biosynthetic process
cell death
Cellular Component
endoplasmic reticulum membrane
mitochondrial membrane
mitochondrion
peroxisomal membrane
peroxisome
membrane
integral to membrane
Molecular Function
lysophospholipase activity
phospholipase activity
calcium-independent phospholipase A2 activity
phosphatidyl phospholipase B activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 776
Molecular Weight 87380.515
Theoretical pI 9.234
Pfam Domain Function
Signals Not Available
Transmembrane Regions
  • 469-489;
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q8K1N1
UniProtKB/Swiss-Prot Entry Name PLPL8_MOUSE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
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  3. Tanaka H, Takeya R, Sumimoto H: A novel intracellular membrane-bound calcium-independent phospholipase A(2). Biochem Biophys Res Commun. 2000 Jun 7;272(2):320-6. [PubMed:10833412 ]
  4. Huttlin EL, Jedrychowski MP, Elias JE, Goswami T, Rad R, Beausoleil SA, Villen J, Haas W, Sowa ME, Gygi SP: A tissue-specific atlas of mouse protein phosphorylation and expression. Cell. 2010 Dec 23;143(7):1174-89. doi: 10.1016/j.cell.2010.12.001. [PubMed:21183079 ]
  5. Park J, Chen Y, Tishkoff DX, Peng C, Tan M, Dai L, Xie Z, Zhang Y, Zwaans BM, Skinner ME, Lombard DB, Zhao Y: SIRT5-mediated lysine desuccinylation impacts diverse metabolic pathways. Mol Cell. 2013 Jun 27;50(6):919-30. doi: 10.1016/j.molcel.2013.06.001. [PubMed:23806337 ]
  6. Mancuso DJ, Han X, Jenkins CM, Lehman JJ, Sambandam N, Sims HF, Yang J, Yan W, Yang K, Green K, Abendschein DR, Saffitz JE, Gross RW: Dramatic accumulation of triglycerides and precipitation of cardiac hemodynamic dysfunction during brief caloric restriction in transgenic myocardium expressing human calcium-independent phospholipase A2gamma. J Biol Chem. 2007 Mar 23;282(12):9216-27. doi: 10.1074/jbc.M607307200. Epub 2007 Jan 9. [PubMed:17213206 ]
  7. Mancuso DJ, Sims HF, Han X, Jenkins CM, Guan SP, Yang K, Moon SH, Pietka T, Abumrad NA, Schlesinger PH, Gross RW: Genetic ablation of calcium-independent phospholipase A2gamma leads to alterations in mitochondrial lipid metabolism and function resulting in a deficient mitochondrial bioenergetic phenotype. J Biol Chem. 2007 Nov 30;282(48):34611-22. doi: 10.1074/jbc.M707795200. Epub 2007 Oct 8. [PubMed:17923475 ]