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Showing Protein Beta-nerve growth factor (HMDBP13921)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13921
Secondary Accession Numbers None
Name Beta-nerve growth factor
Synonyms
  1. Beta-NGF
Gene Name NGF
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity).
Pathways
  • Apoptosis
  • Calcium signaling pathway
  • Cytokine-cytokine receptor interaction
  • Inflammatory mediator regulation of TRP channels
  • MAPK signaling pathway
  • Neurotrophin signaling pathway
  • PI3K-Akt signaling pathway
  • Rap1 signaling pathway
  • Ras signaling pathway
Reactions Not Available
GO Classification
Biological Process
negative regulation of neuron apoptotic process
memory
transmembrane receptor protein tyrosine kinase signaling pathway
nerve development
regulation of neuron differentiation
neuron projection morphogenesis
regulation of synaptic transmission
nerve growth factor signaling pathway
positive regulation of collateral sprouting
positive regulation of peptidyl-serine phosphorylation
peripheral nervous system development
Cellular Component
dendrite
synaptic vesicle
extracellular space
endosome lumen
axon
Molecular Function
growth factor activity
lipid binding
metalloendopeptidase inhibitor activity
nerve growth factor receptor binding
enzyme inhibitor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 241
Molecular Weight 26915.5
Theoretical pI 9.798
Pfam Domain Function
Signals
  • 1-18;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q9N2F0
UniProtKB/Swiss-Prot Entry Name NGF_GORGO
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Kitano T, Liu YH, Ueda S, Saitou N: Human-specific amino acid changes found in 103 protein-coding genes. Mol Biol Evol. 2004 May;21(5):936-44. Epub 2004 Mar 10. [PubMed:15014171 ]