Hmdb loader

Showing Protein Beta-nerve growth factor (HMDBP13922)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 1 metabolite
Identification
HMDB Protein ID HMDBP13922
Secondary Accession Numbers None
Name Beta-nerve growth factor
Synonyms
  1. Beta-NGF
Gene Name NGF
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems (PubMed:20036257). Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (PubMed:22649032). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse (PubMed:22155786). In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (PubMed:20036257). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer (PubMed:22649032, PubMed:26144237). The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (PubMed:22649032).
Pathways
  • Apoptosis
  • Calcium signaling pathway
  • Cytokine-cytokine receptor interaction
  • Inflammatory mediator regulation of TRP channels
  • MAPK signaling pathway
  • Neurotrophin signaling pathway
  • PI3K-Akt signaling pathway
  • Rap1 signaling pathway
  • Ras signaling pathway
Reactions Not Available
GO Classification
Biological Process
extrinsic apoptotic signaling pathway in absence of ligand
neuron development
activation of cysteine-type endopeptidase activity involved in apoptotic process
negative regulation of neuron apoptotic process
positive regulation of cell proliferation
neuron apoptotic process
regulation of release of sequestered calcium ion into cytosol
positive regulation of protein ubiquitination
positive regulation of neuron differentiation
neuron projection development
positive regulation of axon extension
positive regulation of DNA binding
positive regulation of protein binding
positive regulation of protein phosphorylation
extrinsic apoptotic signaling pathway via death domain receptors
sensory perception of pain
adult locomotory behavior
positive regulation of ERK1 and ERK2 cascade
memory
positive regulation of sequence-specific DNA binding transcription factor activity
positive regulation of stem cell proliferation
positive regulation of neuron projection development
transmembrane receptor protein tyrosine kinase signaling pathway
positive regulation of cell growth
positive regulation of Ras protein signal transduction
nerve development
regulation of neuron differentiation
neuron projection morphogenesis
positive regulation of gene expression
regulation of synaptic transmission
nerve growth factor signaling pathway
positive regulation of collateral sprouting
positive regulation of peptidyl-serine phosphorylation
negative regulation of type B pancreatic cell apoptotic process
positive regulation of neuron maturation
positive regulation of neurotrophin TRK receptor signaling pathway
positive regulation of protein autophosphorylation
regulation of neurotransmitter secretion
circadian rhythm
peripheral nervous system development
Cellular Component
dendrite
endoplasmic reticulum lumen
synaptic vesicle
extracellular region
extracellular space
endosome lumen
neuron projection terminus
axon
Molecular Function
growth factor activity
lipid binding
transmembrane receptor protein tyrosine kinase activator activity
metalloendopeptidase inhibitor activity
nerve growth factor receptor binding
cysteine-type endopeptidase activator activity involved in apoptotic process
death receptor agonist activity
enzyme inhibitor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 241
Molecular Weight 27076.47
Theoretical pI 9.46
Pfam Domain Function
Signals
  • 1-18;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P01139
UniProtKB/Swiss-Prot Entry Name NGF_MOUSE
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Ullrich A, Gray A, Berman C, Dull TJ: Human beta-nerve growth factor gene sequence highly homologous to that of mouse. Nature. 1983 Jun 30;303(5920):821-5. [PubMed:6688123 ]
  2. Ullrich A, Gray A, Berman C, Coussens L, Dull TJ: Sequence homology of human and mouse beta-NGF subunit genes. Cold Spring Harb Symp Quant Biol. 1983;48 Pt 1:435-42. [PubMed:6327169 ]
  3. Scott J, Selby M, Urdea M, Quiroga M, Bell GI, Rutter WJ: Isolation and nucleotide sequence of a cDNA encoding the precursor of mouse nerve growth factor. Nature. 1983 Apr 7;302(5908):538-40. doi: 10.1038/302538a0. [PubMed:6336309 ]
  4. Selby MJ, Edwards R, Sharp F, Rutter WJ: Mouse nerve growth factor gene: structure and expression. Mol Cell Biol. 1987 Sep;7(9):3057-64. doi: 10.1128/mcb.7.9.3057-3064.1987. [PubMed:3670305 ]
  5. Yamamoto T, Yamakuni T, Okabe N, Amano T: Production and secretion of nerve growth factor by clonal striated muscle cell line, G8-1. Neurochem Int. 1992 Sep;21(2):251-8. doi: 10.1016/0197-0186(92)90155-k. [PubMed:1284621 ]
  6. Angeletti RH, Hermodson MA, Bradshaw RA: Amino acid sequences of mouse 2.5S nerve growth factor. II. Isolation and characterization of the thermolytic and peptic peptides and the complete covalent structure. Biochemistry. 1973 Jan 2;12(1):100-15. doi: 10.1021/bi00725a018. [PubMed:4566923 ]
  7. Baeza-Raja B, Eckel-Mahan K, Zhang L, Vagena E, Tsigelny IF, Sassone-Corsi P, Ptacek LJ, Akassoglou K: p75 neurotrophin receptor is a clock gene that regulates oscillatory components of circadian and metabolic networks. J Neurosci. 2013 Jun 19;33(25):10221-34. doi: 10.1523/JNEUROSCI.2757-12.2013. [PubMed:23785138 ]
  8. Glerup S, Olsen D, Vaegter CB, Gustafsen C, Sjoegaard SS, Hermey G, Kjolby M, Molgaard S, Ulrichsen M, Boggild S, Skeldal S, Fjorback AN, Nyengaard JR, Jacobsen J, Bender D, Bjarkam CR, Sorensen ES, Fuchtbauer EM, Eichele G, Madsen P, Willnow TE, Petersen CM, Nykjaer A: SorCS2 regulates dopaminergic wiring and is processed into an apoptotic two-chain receptor in peripheral glia. Neuron. 2014 Jun 4;82(5):1074-87. doi: 10.1016/j.neuron.2014.04.022. [PubMed:24908487 ]
  9. McDonald NQ, Lapatto R, Murray-Rust J, Gunning J, Wlodawer A, Blundell TL: New protein fold revealed by a 2.3-A resolution crystal structure of nerve growth factor. Nature. 1991 Dec 5;354(6352):411-4. doi: 10.1038/354411a0. [PubMed:1956407 ]
  10. Holland DR, Cousens LS, Meng W, Matthews BW: Nerve growth factor in different crystal forms displays structural flexibility and reveals zinc binding sites. J Mol Biol. 1994 Jun 10;239(3):385-400. doi: 10.1006/jmbi.1994.1380. [PubMed:8201620 ]
  11. Bax B, Blundell TL, Murray-Rust J, McDonald NQ: Structure of mouse 7S NGF: a complex of nerve growth factor with four binding proteins. Structure. 1997 Oct 15;5(10):1275-85. doi: 10.1016/s0969-2126(97)00280-3. [PubMed:9351801 ]
  12. Feng D, Kim T, Ozkan E, Light M, Torkin R, Teng KK, Hempstead BL, Garcia KC: Molecular and structural insight into proNGF engagement of p75NTR and sortilin. J Mol Biol. 2010 Mar 5;396(4):967-84. doi: 10.1016/j.jmb.2009.12.030. Epub 2009 Dec 28. [PubMed:20036257 ]
  13. Tong Q, Wang F, Zhou HZ, Sun HL, Song H, Shu YY, Gong Y, Zhang WT, Cai TX, Yang FQ, Tang J, Jiang T: Structural and functional insights into lipid-bound nerve growth factors. FASEB J. 2012 Sep;26(9):3811-21. doi: 10.1096/fj.12-207316. Epub 2012 May 30. [PubMed:22649032 ]
  14. Sun HL, Jiang T: The structure of nerve growth factor in complex with lysophosphatidylinositol. Acta Crystallogr F Struct Biol Commun. 2015 Jul;71(Pt 7):906-12. doi: 10.1107/S2053230X15008870. Epub 2015 Jun 27. [PubMed:26144237 ]