| Identification |
|---|
| HMDB Protein ID
| HMDBP13924 |
| Secondary Accession Numbers
| None |
| Name
| Beta-nerve growth factor |
| Synonyms
|
- Beta-NGF
|
| Gene Name
| NGF |
| Protein Type
| Unknown |
| Biological Properties |
|---|
| General Function
| Not Available |
| Specific Function
| Nerve growth factor is important for the development and maintenance of the sympathetic and sensory nervous systems. Extracellular ligand for the NTRK1 and NGFR receptors, activates cellular signaling cascades to regulate neuronal proliferation, differentiation and survival (By similarity). The immature NGF precursor (proNGF) functions as ligand for the heterodimeric receptor formed by SORCS2 and NGFR, and activates cellular signaling cascades that lead to inactivation of RAC1 and/or RAC2, reorganization of the actin cytoskeleton and neuronal growth cone collapse. In contrast to mature NGF, the precursor form (proNGF) promotes neuronal apoptosis (in vitro) (By similarity). Inhibits metalloproteinase-dependent proteolysis of platelet glycoprotein VI (By similarity). Binds lysophosphatidylinositol and lysophosphatidylserine between the two chains of the homodimer. The lipid-bound form promotes histamine relase from mast cells, contrary to the lipid-free form (By similarity). |
| Pathways
|
- Apoptosis
- Calcium signaling pathway
- Cytokine-cytokine receptor interaction
- Inflammatory mediator regulation of TRP channels
- MAPK signaling pathway
- Neurotrophin signaling pathway
- PI3K-Akt signaling pathway
- Rap1 signaling pathway
- Ras signaling pathway
|
| Reactions
| Not Available |
| GO Classification
|
| Biological Process |
| negative regulation of neuron apoptotic process |
| memory |
| transmembrane receptor protein tyrosine kinase signaling pathway |
| nerve development |
| regulation of neuron differentiation |
| neuron projection morphogenesis |
| regulation of synaptic transmission |
| nerve growth factor signaling pathway |
| positive regulation of collateral sprouting |
| positive regulation of peptidyl-serine phosphorylation |
| peripheral nervous system development |
| Cellular Component |
| dendrite |
| synaptic vesicle |
| extracellular space |
| endosome lumen |
| axon |
| Molecular Function |
| growth factor activity |
| lipid binding |
| metalloendopeptidase inhibitor activity |
| nerve growth factor receptor binding |
| enzyme inhibitor activity |
|
| Cellular Location
|
Not Available
|
| Gene Properties |
|---|
| Chromosome Location
| Not Available |
| Locus
| Not Available |
| SNPs
| Not Available |
| Gene Sequence
|
Not Available
|
| Protein Properties |
|---|
| Number of Residues
| 241 |
| Molecular Weight
| 26887.41 |
| Theoretical pI
| 9.798 |
| Pfam Domain Function
|
|
| Signals
|
|
|
Transmembrane Regions
|
Not Available
|
| Protein Sequence
|
Not Available
|
| External Links |
|---|
| GenBank ID Protein
| Not Available |
| UniProtKB/Swiss-Prot ID
| Q9N2F1 |
| UniProtKB/Swiss-Prot Entry Name
| NGF_PANTR |
| PDB IDs
|
Not Available |
| GenBank Gene ID
| Not Available |
| GeneCard ID
| Not Available |
| GenAtlas ID
| Not Available |
| HGNC ID
| Not Available |
| References |
|---|
| General References
| - Kitano T, Liu YH, Ueda S, Saitou N: Human-specific amino acid changes found in 103 protein-coding genes. Mol Biol Evol. 2004 May;21(5):936-44. Epub 2004 Mar 10. [PubMed:15014171 ]
- Dorus S, Vallender EJ, Evans PD, Anderson JR, Gilbert SL, Mahowald M, Wyckoff GJ, Malcom CM, Lahn BT: Accelerated evolution of nervous system genes in the origin of Homo sapiens. Cell. 2004 Dec 29;119(7):1027-40. [PubMed:15620360 ]
|
