Hmdb loader
Identification
HMDB Protein ID HMDBP13956
Secondary Accession Numbers None
Name Cysteine proteinase inhibitor 1
Synonyms
  1. KCPI1
  2. Phytocystatin
Gene Name Not Available
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Specific inhibitor of papain family cysteine proteinases. Inhibits papain, chymopapain, bromelain, ficin, human cathepsins B, H and L, actinidain and house dustmite endopeptidase 1, but does not inhibit human bleomycin hydrolase. Inhibits papain with an IC(50) of 2.47 nM. Does not inhibit cysteine proteinases belonging to other families including clostripain, streptopain and calpain.
Pathways Not Available
Reactions Not Available
GO Classification
Biological Process
defense response
Cellular Component
extracellular region
Molecular Function
cysteine-type endopeptidase inhibitor activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues Not Available
Molecular Weight 12755.665
Theoretical pI Not Available
Pfam Domain Function
Signals
  • 1-26;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID Q6TPK4
UniProtKB/Swiss-Prot Entry Name CYT1_ACTDE
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Rassam M, Laing WA: Purification and characterization of phytocystatins from kiwifruit cortex and seeds. Phytochemistry. 2004 Jan;65(1):19-30. doi: 10.1016/j.phytochem.2003.09.019. [PubMed:14697268 ]
  2. Popovic MM, Milovanovic M, Burazer L, Vuckovic O, Hoffmann-Sommergruber K, Knulst AC, Lindner B, Petersen A, Jankov R, Gavrovic-Jankulovic M: Cysteine proteinase inhibitor Act d 4 is a functional allergen contributing to the clinical symptoms of kiwifruit allergy. Mol Nutr Food Res. 2010 Mar;54(3):373-80. doi: 10.1002/mnfr.200900035. [PubMed:19885843 ]
  3. Bublin M, Mari A, Ebner C, Knulst A, Scheiner O, Hoffmann-Sommergruber K, Breiteneder H, Radauer C: IgE sensitization profiles toward green and gold kiwifruits differ among patients allergic to kiwifruit from 3 European countries. J Allergy Clin Immunol. 2004 Nov;114(5):1169-75. doi: 10.1016/j.jaci.2004.07.016. [PubMed:15536427 ]