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Showing Protein Beta-hexosaminidase subunit A1 (HMDBP13972)

IdentificationBiological propertiesGene propertiesProtein propertiesExternal linksReferencesXMLShow 0 metabolites
Identification
HMDB Protein ID HMDBP13972
Secondary Accession Numbers None
Name Beta-hexosaminidase subunit A1
Synonyms
  1. Beta-N-acetylhexosaminidase subunit A1
  2. N-acetyl-beta-glucosaminidase subunit A1
Gene Name HEXA1
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Responsible for the degradation of GM2 gangliosides, and a variety of other molecules containing terminal N-acetyl hexosamines. This enzyme plays a role during the slug stage of development in the maintenance of pseudoplasmodia of normal size.
Pathways
  • Amino sugar and nucleotide sugar metabolism
  • Glycosaminoglycan degradation
  • Glycosphingolipid biosynthesis - ganglio series
  • Glycosphingolipid biosynthesis - globo and isoglobo series
  • Other glycan degradation
  • Various types of N-glycan biosynthesis
Reactions Not Available
GO Classification
Biological Process
carbohydrate metabolic process
Cellular Component
lysosome
Molecular Function
N-acetyl-beta-D-galactosaminidase activity
beta-N-acetylhexosaminidase activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 532
Molecular Weight 59787.075
Theoretical pI 4.742
Pfam Domain Function
Signals
  • 1-18;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P13723
UniProtKB/Swiss-Prot Entry Name HEXA1_DICDI
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Graham TR, Zassenhaus HP, Kaplan A: Molecular cloning of the cDNA which encodes beta-N-acetylhexosaminidase A from Dictyostelium discoideum. Complete amino acid sequence and homology with the human enzyme. J Biol Chem. 1988 Nov 15;263(32):16823-9. [PubMed:2972716 ]
  2. Eichinger L, Pachebat JA, Glockner G, Rajandream MA, Sucgang R, Berriman M, Song J, Olsen R, Szafranski K, Xu Q, Tunggal B, Kummerfeld S, Madera M, Konfortov BA, Rivero F, Bankier AT, Lehmann R, Hamlin N, Davies R, Gaudet P, Fey P, Pilcher K, Chen G, Saunders D, Sodergren E, Davis P, Kerhornou A, Nie X, Hall N, Anjard C, Hemphill L, Bason N, Farbrother P, Desany B, Just E, Morio T, Rost R, Churcher C, Cooper J, Haydock S, van Driessche N, Cronin A, Goodhead I, Muzny D, Mourier T, Pain A, Lu M, Harper D, Lindsay R, Hauser H, James K, Quiles M, Madan Babu M, Saito T, Buchrieser C, Wardroper A, Felder M, Thangavelu M, Johnson D, Knights A, Loulseged H, Mungall K, Oliver K, Price C, Quail MA, Urushihara H, Hernandez J, Rabbinowitsch E, Steffen D, Sanders M, Ma J, Kohara Y, Sharp S, Simmonds M, Spiegler S, Tivey A, Sugano S, White B, Walker D, Woodward J, Winckler T, Tanaka Y, Shaulsky G, Schleicher M, Weinstock G, Rosenthal A, Cox EC, Chisholm RL, Gibbs R, Loomis WF, Platzer M, Kay RR, Williams J, Dear PH, Noegel AA, Barrell B, Kuspa A: The genome of the social amoeba Dictyostelium discoideum. Nature. 2005 May 5;435(7038):43-57. doi: 10.1038/nature03481. [PubMed:15875012 ]
  3. Loomis WF: Genetic analysis of the gene for N-acetylglucosaminidase in Dictyostelium discoideum. Genetics. 1978 Feb;88(2):277-84. doi: 10.1093/genetics/88.2.277. [PubMed:640375 ]