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Identification
HMDB Protein ID HMDBP13978
Secondary Accession Numbers None
Name Neurotensin/neuromedin N
Synonyms Not Available
Gene Name NTS
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.
Pathways
  • Neuroactive ligand-receptor interaction
Reactions Not Available
GO Classification
Biological Process
signal transduction
G-protein coupled receptor signaling pathway
neuropeptide signaling pathway
antimicrobial humoral immune response mediated by antimicrobial peptide
killing of cells of other organism
Cellular Component
axon terminus
extracellular region
transport vesicle
intracellular membrane-bounded organelle
Molecular Function
neuropeptide receptor binding
receptor ligand activity
neuropeptide hormone activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 170
Molecular Weight 19794.765
Theoretical pI 7.086
Pfam Domain Function
Signals
  • 1-23;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P30990
UniProtKB/Swiss-Prot Entry Name NEUT_HUMAN
PDB IDs
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
References
General References
  1. Gerhard DS, Wagner L, Feingold EA, Shenmen CM, Grouse LH, Schuler G, Klein SL, Old S, Rasooly R, Good P, Guyer M, Peck AM, Derge JG, Lipman D, Collins FS, Jang W, Sherry S, Feolo M, Misquitta L, Lee E, Rotmistrovsky K, Greenhut SF, Schaefer CF, Buetow K, Bonner TI, Haussler D, Kent J, Kiekhaus M, Furey T, Brent M, Prange C, Schreiber K, Shapiro N, Bhat NK, Hopkins RF, Hsie F, Driscoll T, Soares MB, Casavant TL, Scheetz TE, Brown-stein MJ, Usdin TB, Toshiyuki S, Carninci P, Piao Y, Dudekula DB, Ko MS, Kawakami K, Suzuki Y, Sugano S, Gruber CE, Smith MR, Simmons B, Moore T, Waterman R, Johnson SL, Ruan Y, Wei CL, Mathavan S, Gunaratne PH, Wu J, Garcia AM, Hulyk SW, Fuh E, Yuan Y, Sneed A, Kowis C, Hodgson A, Muzny DM, McPherson J, Gibbs RA, Fahey J, Helton E, Ketteman M, Madan A, Rodrigues S, Sanchez A, Whiting M, Madari A, Young AC, Wetherby KD, Granite SJ, Kwong PN, Brinkley CP, Pearson RL, Bouffard GG, Blakesly RW, Green ED, Dickson MC, Rodriguez AC, Grimwood J, Schmutz J, Myers RM, Butterfield YS, Griffith M, Griffith OL, Krzywinski MI, Liao N, Morin R, Palmquist D, Petrescu AS, Skalska U, Smailus DE, Stott JM, Schnerch A, Schein JE, Jones SJ, Holt RA, Baross A, Marra MA, Clifton S, Makowski KA, Bosak S, Malek J: The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). Genome Res. 2004 Oct;14(10B):2121-7. [PubMed:15489334 ]
  2. Dong Z, Wang X, Zhao Q, Townsend CM Jr, Evers BM: DNA methylation contributes to expression of the human neurotensin/neuromedin N gene. Am J Physiol. 1998 Mar;274(3 Pt 1):G535-43. [PubMed:9530155 ]
  3. Bean AJ, Dagerlind A, Hokfelt T, Dobner PR: Cloning of human neurotensin/neuromedin N genomic sequences and expression in the ventral mesencephalon of schizophrenics and age/sex matched controls. Neuroscience. 1992 Sep;50(2):259-68. [PubMed:1436492 ]
  4. Quistgaard EM, Madsen P, Groftehauge MK, Nissen P, Petersen CM, Thirup SS: Ligands bind to Sortilin in the tunnel of a ten-bladed beta-propeller domain. Nat Struct Mol Biol. 2009 Jan;16(1):96-8. doi: 10.1038/nsmb.1543. Epub 2009 Jan 4. [PubMed:19122660 ]
  5. Jacobsen L, Madsen P, Jacobsen C, Nielsen MS, Gliemann J, Petersen CM: Activation and functional characterization of the mosaic receptor SorLA/LR11. J Biol Chem. 2001 Jun 22;276(25):22788-96. doi: 10.1074/jbc.M100857200. Epub 2001 Apr 9. [PubMed:11294867 ]
  6. Da Costa G, Bondon A, Coutant J, Curmi P, Monti JP: Intermolecular interactions between the neurotensin and the third extracellular loop of human neurotensin 1 receptor. J Biomol Struct Dyn. 2013 Dec;31(12):1381-92. doi: 10.1080/07391102.2012.736776. Epub 2012 Nov 12. [PubMed:23140271 ]