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HMDB Protein ID HMDBP14007
Secondary Accession Numbers None
Name Interferon alpha-16
  1. IFN-alpha-16
  2. Interferon alpha-WA
Gene Name IFNA16
Protein Type Unknown
Biological Properties
General Function Not Available
Specific Function Produced by macrophages, IFN-alpha have antiviral activities. Interferon stimulates the production of two enzymes: a protein kinase and an oligoadenylate synthetase.
  • Autoimmune thyroid disease
  • Coronavirus disease - COVID-19
  • Cytokine-cytokine receptor interaction
  • Cytosolic DNA-sensing pathway
  • Epstein-Barr virus infection
  • Hepatitis B
  • Hepatitis C
  • Herpes simplex virus 1 infection
  • Human cytomegalovirus infection
  • Human immunodeficiency virus 1 infection
  • Human papillomavirus infection
  • Influenza A
  • JAK-STAT signaling pathway
  • Kaposi sarcoma-associated herpesvirus infection
  • Lipid and atherosclerosis
  • Measles
  • Natural killer cell mediated cytotoxicity
  • Necroptosis
  • NOD-like receptor signaling pathway
  • PI3K-Akt signaling pathway
  • RIG-I-like receptor signaling pathway
  • Toll-like receptor signaling pathway
  • Tuberculosis
Reactions Not Available
GO Classification
Biological Process
response to exogenous dsRNA
natural killer cell activation involved in immune response
positive regulation of peptidyl-serine phosphorylation of STAT protein
T cell activation involved in immune response
type I interferon-mediated signaling pathway
B cell differentiation
B cell proliferation
blood coagulation
defense response to virus
humoral immune response
adaptive immune response
cytokine-mediated signaling pathway
Cellular Component
extracellular region
extracellular space
Molecular Function
type I interferon receptor binding
cytokine activity
Cellular Location Not Available
Gene Properties
Chromosome Location Not Available
Locus Not Available
SNPs Not Available
Gene Sequence Not Available
Protein Properties
Number of Residues 189
Molecular Weight 21710.85
Theoretical pI 6.761
Pfam Domain Function
  • 1-23;
Transmembrane Regions Not Available
Protein Sequence Not Available
GenBank ID Protein Not Available
UniProtKB/Swiss-Prot ID P05015
UniProtKB/Swiss-Prot Entry Name IFN16_HUMAN
PDB IDs Not Available
GenBank Gene ID Not Available
GeneCard ID Not Available
GenAtlas ID Not Available
HGNC ID Not Available
General References
  1. Humphray SJ, Oliver K, Hunt AR, Plumb RW, Loveland JE, Howe KL, Andrews TD, Searle S, Hunt SE, Scott CE, Jones MC, Ainscough R, Almeida JP, Ambrose KD, Ashwell RI, Babbage AK, Babbage S, Bagguley CL, Bailey J, Banerjee R, Barker DJ, Barlow KF, Bates K, Beasley H, Beasley O, Bird CP, Bray-Allen S, Brown AJ, Brown JY, Burford D, Burrill W, Burton J, Carder C, Carter NP, Chapman JC, Chen Y, Clarke G, Clark SY, Clee CM, Clegg S, Collier RE, Corby N, Crosier M, Cummings AT, Davies J, Dhami P, Dunn M, Dutta I, Dyer LW, Earthrowl ME, Faulkner L, Fleming CJ, Frankish A, Frankland JA, French L, Fricker DG, Garner P, Garnett J, Ghori J, Gilbert JG, Glison C, Grafham DV, Gribble S, Griffiths C, Griffiths-Jones S, Grocock R, Guy J, Hall RE, Hammond S, Harley JL, Harrison ES, Hart EA, Heath PD, Henderson CD, Hopkins BL, Howard PJ, Howden PJ, Huckle E, Johnson C, Johnson D, Joy AA, Kay M, Keenan S, Kershaw JK, Kimberley AM, King A, Knights A, Laird GK, Langford C, Lawlor S, Leongamornlert DA, Leversha M, Lloyd C, Lloyd DM, Lovell J, Martin S, Mashreghi-Mohammadi M, Matthews L, McLaren S, McLay KE, McMurray A, Milne S, Nickerson T, Nisbett J, Nordsiek G, Pearce AV, Peck AI, Porter KM, Pandian R, Pelan S, Phillimore B, Povey S, Ramsey Y, Rand V, Scharfe M, Sehra HK, Shownkeen R, Sims SK, Skuce CD, Smith M, Steward CA, Swarbreck D, Sycamore N, Tester J, Thorpe A, Tracey A, Tromans A, Thomas DW, Wall M, Wallis JM, West AP, Whitehead SL, Willey DL, Williams SA, Wilming L, Wray PW, Young L, Ashurst JL, Coulson A, Blocker H, Durbin R, Sulston JE, Hubbard T, Jackson MJ, Bentley DR, Beck S, Rogers J, Dunham I: DNA sequence and analysis of human chromosome 9. Nature. 2004 May 27;429(6990):369-74. [PubMed:15164053 ]
  2. Gren E, Berzin V, Jansone I, Tsimanis A, Vishnevsky Y, Apsalons U: Novel human leukocyte interferon subtype and structural comparison of alpha interferon genes. J Interferon Res. 1984 Fall;4(4):609-17. doi: 10.1089/jir.1984.4.609. [PubMed:6548765 ]
  3. Henco K, Brosius J, Fujisawa A, Fujisawa JI, Haynes JR, Hochstadt J, Kovacic T, Pasek M, Schambock A, Schmid J, et al.: Structural relationship of human interferon alpha genes and pseudogenes. J Mol Biol. 1985 Sep 20;185(2):227-60. doi: 10.1016/0022-2836(85)90401-2. [PubMed:4057246 ]
  4. Torczynski RM, Fuke M, Bollon AP: Human genomic library screened with 17-base oligonucleotide probes yields a novel interferon gene. Proc Natl Acad Sci U S A. 1984 Oct;81(20):6451-5. doi: 10.1073/pnas.81.20.6451. [PubMed:6387705 ]